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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Method to Guarantee Quality of Radiotherapy Planning

    SBC: ADVANCED PROCESS COMBINATORICS, INC.            Topic: N/A

    This project will produce a method for constructing treatment plans with a guarantee on the quality of the solution. The plans produced by current techniques can fall short of the optimum or needlessly fail to satisfy constraints. As a result, the search for an improved solution is open-ended, exhausting hospital resources and manpower, and providing no assurance to patient or physician that a b ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  2. SUPERCONDUCTING MAGNET FOR MICROCOIL NMR

    SBC: American Magnetics, Inc.            Topic: N/A

    DESCRIPTION (Verbatim from the Applicant's Abstract): The specific aims of this Phase I STTR project, proposed by the American Magnetics, Inc. in partnership with the MIT Francis Bitter Magnet Laboratory, are: 1) experimental demonstration of feasibility of innovative design and operation features applicable to NMR Nb3Sn-magnet/cryocooler systems; and 2) co ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  3. NOVEL THERAPEUTIC APPROACH TO PSORIASIS

    SBC: BETHESDA PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (Applicant's abstract): Psoriasis is a common, inflammatory disease of the skin characterized by hyper-proliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. Thiaz ...

    STTR Phase II 2001 Department of Health and Human ServicesNational Institutes of Health
  4. NOVEL THERAPEUTIC APPROACH TO PSORIASIS

    SBC: BETHESDA PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (Applicant's abstract): Psoriasis is a common, inflammatory disease of the skin characterized by hyper-proliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. Thiaz ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  5. Biomaterials for Orbit Reconstruction

    SBC: BIOMIMESYS, INC.            Topic: N/A

    DESCRIPTION (Verbatim from Applicant): We will develop biomimetic materials for repair and orthoplasty of the orbit and surrounding bony structures. These scaffolds will incorporate a cell binding peptide related to collagen which will allow them to serve as collagen-like anchorages for cells. These Collagen Surrogate Matrices (CSM) will facilitate haptotactic migrati ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  6. Hydroxyl radical mapping of protein interfaces

    SBC: EXSAR CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Identifying amino acid residues of a protein that form the binding site for a drug, or that are present at the interface in a protein-protein complex are difficult to identify from the crystal structures of the individual partner proteins. Carta Proteomics is committed to the premise that monitoring isotope exchange in ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  7. Chelate Based Scaffolds (Chelabody) In Tumor Targeting

    SBC: COMCHEM TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The current paradigm in therapeutic nuclear medicine is to optimize receptor binding molecules and then add on a moiety capable of carrying a radioisotope. This "afterthought" modification process results in suboptimum performance for such agents when dealing with molecules smaller than monoclo ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  8. Parametric models for survival analysis

    SBC: EPICENTER SOFTWARE            Topic: N/A

    DESCRIPTION (provided by applicant): The most commonly used statistical methods for the design and analysis of cancer clinical trials today rely heavily on the idea of proportional hazards or its generalizations; i.e., that the important differences between treatments are reflected in the differences between failure rates. Implicit in the use of these methods is the assumptio ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  9. Single Vector Dual Gene Therapy

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (Applicant's Abstract): Primary pulmonary hypertension (PPH) is uniformly fatal and has no known cure. A major pathogenic factor in PPH is decreased synthesis of the vacillator prostaglandin 12 (PG 12) and excess synthesis of the vasoconstrictor prostanoid, thromboxane A2 (TxA2). The investigators have shown in an animal model of acute pulmona ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  10. Alpha-1 Antitrypsin Gene Therapy for Cystic Fibrosis

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (Applicant's Abstract): The investigators have developed a plasmid vector that expresses the normal human alpha-1 antitrypsin (AAT) gene in human respiratory epithelium when delivered as a plasmid-cationic liposome complex. In subjects with inherited AAT deficiency, they showed that liposome mediated transfer of the normal AAT gene to the nasal respiratory epi ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
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