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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Prediction of Strutural Response and Fluid-Induced Vibration in Turbomachinery

    SBC: CFD Research Corporation            Topic: T102

    Advanced turbomachinery components play a critical role in launch vehicle and spacecraft liquid rocket propulsion systems. To achieve desired efficiencies, extremely tight tolerances are often imposed between inducer blades and shrouds or other system components which sets up strong interactions that influence both the aerodynamics and the structural performance of blades and vanes. These transien ...

    STTR Phase I 2016 National Aeronautics and Space Administration
  2. Unified In-Space Propulsion Framework for Prediction of Plume-Induced Spacecraft Environments

    SBC: CFD Research Corporation            Topic: T102

    Chemical contamination of spacecraft components as well as thermal and force loading from firing liquid propellant thrusters are critical concerns for in-space propulsion applications. Gas molecular contamination and liquid droplet deposition due to incomplete combustion threaten to damage surface materials, sensitive instruments and optical sensors, and poses major risks for mission success. Liqu ...

    STTR Phase I 2016 National Aeronautics and Space Administration
  3. Visualizing and Comparing Exploration Plan Alternatives and Change Effects (xPACE)

    SBC: Traclabs Inc.            Topic: T1101

    Future human space flight missions will take astronauts deeper into space and require increased crew independence from Earth-based flight controllers (crew autonomy). Consequently, they will need to perform more tasks and a greater diversity of tasks. A critical resource for meeting these challenges is greater reliance on robots that can operate with more autonomously [NASA Roadmap TA4]. Greater r ...

    STTR Phase I 2016 National Aeronautics and Space Administration
  4. Mega-Watt Class High Voltage, Variable Frequency, Propulsor Power Unit

    SBC: Balcones Technologies LLC            Topic: T1501

    Balcones Technologies, LLC (BT) proposes to adapt technologies developed by and resident in BT and The University of Texas at Austin Center for Electromechanics (CEM) in the area of advanced high efficiency, high-power density motors/generators and propulsion power train systems to address SBIR 2016 Subtopic T15.01 Power Systems for Hybrid Electric Propulsion. In particular, our team will develop ...

    STTR Phase I 2016 National Aeronautics and Space Administration
  5. Developing a novel adjuvant system for therapeutic vaccines against lung cancer

    SBC: FasCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Therapeutics is focused on the development of adjuvant systems with desired immune activities for targeted indications The Companyandapos s immune stimulatory adjuvant platform builds on combinatorial use of immune agonists with distinct immune targets and mechanisms of action for the generation of therapeutic immune responses Critical to this platform techno ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a small molecule activator of integrin cell adhesion to enhance therapeutic responses to checkpoint blockade in cancer

    SBC: 7 Hills Pharma LLC            Topic: 102

    DESCRIPTION provided by applicant Recent FDA approvals of ipilimumab nivolumab and pembrolizumab which target checkpoint receptors cytotoxic T lymphocyte associated antigen CTLA and programmed death PD have ushered in a new era of cancer immunotherapy in metastatic melanoma Despite unprecedented overall survival benefits with combination therapy the incidence of complete respo ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Temozolomide Perillyl Alcohol Conjugate as Treatment for Recurrent Malignant Brain tumors

    SBC: Neonc Technologies, Inc.            Topic: BT

    DESCRIPTION provided by applicant Glioblastoma multiforme GBM the most common and malignant of all gliomas has a median survival time of months Standard of care chemotherapy using temozolomide TMZ is effective initially but the GBM inevitably recurs and these recurrent tumors are resistant to TMZ There are currently no effective treatment options for patients with TMZ resistant ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Bone targeted antimicrobials for biofilm-mediated osteolytic infection treatment

    SBC: BIOVINC, LLC            Topic: NIDCR

    DESCRIPTION provided by applicant Infectious bone disease is a major cause of morbidity and mortality worldwide Successful treatment often requires surgical intervention with longer term antibiotic therapy Bacterial biofilm pathogens are associated with most osseous infections and represent a major target of therapy The biofilm pathogens associated with chronic bone infections bind to and co ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Mobile Intervention Kit to Increase HIV/HCV Testing and Overdose Prevention Training

    SBC: Digital Health Empowerment, Inc            Topic: NIDA

    DESCRIPTION provided by applicant Because many people who inject drugs PWID do not receive adequate information about HIV or HCV testing and prevention or overdose prevention and response training we propose to develop a Mobile Intervention Kit to deliver technology based interventions from a library of theory guided video content The first iteration will address overdose prevention and r ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Targeted Epigenetic Therapy for Triple-Negative Breast Cancer

    SBC: PARKSIDE SCIENTIFIC INC.            Topic: 102

    DESCRIPTIONprovided by applicantTriple negative breast cancerTNBCis one of the most aggressive forms of human cancerand currently has no targeted therapyChemotherapy is the only available treatment for TNBC patientsbut is deleterious and not effective once tumor spreadsTNBC represents a major unmet medical needaboutof breast cancer incidenceswomen worldwide inare TNBCTNBC disproportionally affects ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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