Award Data

A Rapid Paper Strip Nucleic Acid Test for the Point of Care Detection of Zika virus CrossLife Technologies Inc Project Summary Abstract There are unmet needs for nucleic acids new diagnostics that can be applied at the point of care to detect Zika Virus ZIKV infections A highly sensitive simple paper strip molecular test that detects ZIKV at the point of care will be developed The target seq ...

Project Summary Monoclonal antibodies mAbs are a well validated drug platform with exquisite specificity diversity and potency They offer the lowest risk class of drug for development through licensure and offer great potential for addressing emerging and re emerging infectious diseases To be prepared as threats like Ebola EBOV Marburg MARV and Zika viruses continue to emerge or re em ...

PROJECT SUMMARY The aim of this proposal is to develop a rapid low cost and easy to use POC diagnostic test for Zika virus ZIKV ZIKV is an emerging mosquito borne Flavivirus that has gained global attention due to new evidence that it is linked to birth defect microcephaly Additionally health experts are also concerned about the link between the virus and Guillain Barr syndrome GBS Pres ...

The proposed project aims to build a diagnostic test for chronic T cruzi infection and Chagas disease that not only improves testing performance but that can be readily integrated with similarly developed tests for most clinically important parasitoses Current assays for Chagas disease and other parasitic infections lack desired levels of specificity and require multiple independent assays an ...

Human rhinovirus RV is the predominant etiological agent of the common cold and the leading cause of human infectious disease RV is more than a nuisance It is a major cause of community acquired pneumonia in children and adults in the United States and plays a major role in triggering exacerbations of both asthma and chronic obstructive pulmonary disease resulting in billions of dollars in me ...

PROJECT SUMMARY ABSTRACT Members of the Candida genus of fungi form part of the normal human microbiota but are also opportunistic pathogens capable of causing serious mucosal and systemic infectionsCandida cells grow and divide in suspensionplanktonicculturesbut they also form resilient and drug resistant biofilmsorganizedtightlypacked communities of cells attached to a surfaceBiofilms colonize m ...

ABSTRACT This program aims to develop a method for banking clinical grade bone marrow from cadaveric donors that can be deployed nationally to ameliorate shortages provide bone marrow stockpiles as medical countermeasures for nuclear threats and support existing research approaches such as delayed immune tolerance induction and transfusion of HIV resistant stem cells We will adapt a method de ...

No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseases Spanning multiple organ systems clinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritis RA and systemic lupus erythematosus SLE RA is a sym ...

Project Summary Hyper inflammation induced by bacteria or bacterial products through toll like receptor TLR leads to sepsis and hence current approaches are directed towards blockade of such receptors While many such candidate antagonists have shown promise they also result in induction of inappropriate innate immune responses thus increasing risk of development of shock leading to death W ...

PROJECT SUMMARY The Dengue DENV and Chikungunya viruses CHIKV are primarily transmitted by two types of mosquitoes the Aedes aegypti and the Aedes albopictus Patients infected by DENV may experience dengue fever dengue hemorrhagic fever DHF and dengue shock syndrome DSS DHF and DSS could be fatal and are of particular public health concern in endemic regions of the U S Africa Asia ...