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Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

Establish a radiation-aware analysis capability in a commercial EDA design flow that will enable first-pass success in radiation-hardened by design (RHBD) for DoD ASICs in much the same way that existing EDA design suites ensure first pass functionality and performance success of complex ASICs destined for commercial applications. Layout-aware, calibrated single-event radiation models that captur ...

THE PHASE I RESEARCH WILL COMPLETE DEVELOPMENT OF A MATHEMATICAL MODEL AND CONDUCT CONTINUOUS FLOW BENCH-SCALE STUDIES TO EVALUATE THE FEASIBILITY AND APPLICABILITY OF A PROPOSED ALTERNATIVE OFFGAS VOC CONTROL STRATEGY. THE PROPOSED SYSTEM UTILIZED OFFGAS CAPTURE FROM WASTEWATER TREATMENT AND STORAGE UNITS FOR RECYCLE TO AN AEROBIC BIOLOGICAL TREATMENT PROCESS. THE RECYCLED GAS PHASE WILL INCREASE ...

To generate oxygen enriched gas for injured soldiers via separation from air, the oxygen production devices based on current high temperature membranes technologies are large and consume significant power because the ceramic materials have to operate at high temperatures (>800oC) to achieve acceptable conductivity. Recently developed 2D layered superior oxide-ion conductor Sr3-3xNa3xSi3O9-1.5x (SN ...

The DOD is investing in mobile computing, information and warrior health systems to support network-centric military capabilities. Computerized health records, telemedicine, wearable monitoring, mHealth have the potential to reduce costs, promote health, ensure soldier fitness. The goal of this project is to design, develop, demonstrate, deploy a Warfighter Health Avatar (WHA), a simulation framew ...

Iron deficiency is one of the most common nutritional deficiencies in the United States. Left untreated, iron stores continue to deplete, resulting in iron deficiency anemia. Women undergoing basic military training are particularly susceptible to reduced iron stores. To date, there are no comprehensive point-of-care instruments for accurate determination of iron status. We propose to develop a no ...

Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...