Award Data

ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

PROJECT SUMMARY The proposed product is an analytical scale UHPLC column for separating protein drugs in native form with the Phase I proposal focused on anion exchange chromatography as the separation mechanism The bonded phase is made of polymer chains in this case bearing weak anion exchange groups The study will be expanded to cation exchange and hydrophobic interaction chromatography in ...

The meteoric rise of personally identifying information (PII) created and shared online is unprecedented. The sheer volume of open source intelligence available on sites such Facebook, Twitter, LinkedIn, message forums, Instagram, etc. makes the task of collecting and organizing OSINT increasingly laborious for analysts. Zeuss has already built and tested an operational product that addresses this ...

PROJECT SUMMARY ABSTRACT As people age they steadily lose bone mass and their bones become fragile and increasingly prone to hip and other fractures and this can prove fatal The American College of Radiology therefore recommends that assessment of bone mineral density BMD be performed in post menopausal women and all people over the age of every two years If indicated preventive measure ...

DESCRIPTION provided by applicant There is an urgent need for a platform technology that can monitor changes in metabolite and protein biomarkers below current detection limits because in many cases the disease has progressed to an advanced state by the time the abundance of the biomarker has become measurable Our molecular motor powered nanodevice linked immunosorbent assay MONA LISA is ...

Even though nonwovens offer significant cost savings over woven fabrics, nonwovens are mostly used for disposable protective clothing, wipes, filters, and geotextiles. The low adoption rate of nonwovens in reusable garments is due to the difficulty in producing fabrics with a combination of desired properties that mimic woven fabrics. For example, a nonwoven with the drapability and air permeabili ...

Complex wounds including traumatic, chemical, chronic or surgical wounds present a significant challenge to care givers. Wound healing, being a complex and multifaceted process, differs significantly based on the type of wound and the underlining health of the patient. It is well established that factors like impaired perfusion, infection, existence of metabolic disorders such as diabetes, bad nut ...

Hostile conflicts leave behind millions of armed landmines in developing countries throughout the globe. Humanitarian demining is hazardous and labor intensive. A promising development in detecting explosives found in landmines is using small, olfactory sensitive animals trained to act as biosensor detectors. However, current manual training methods require skilled trainers following strict pro ...

As the warfighter is increasingly using more highly integrated instruments, e.g. a laser rangefinder (LRF) combined with a laser designator and an imager, the need to decrease the size of these components becomes more important. Compact small munition applications of rangefinders particularly place an emphasis on size of the optical front end. In order to make the transceiver more compact, speci ...

DESCRIPTION provided by applicant We propose to develop a non invasive device to enable children with urea cycle disorders and their parents guardians and physicians to actively manage the disorder at home and improve outcomes in the clinic Urea cycle disorders UCD are inborn errors of metabolism that impair oneandapos s ability to convert ammonia NH a neurotoxin into urea which is ...