Award Data

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...

A critical aspect of exoskeleton control that has to date introduced a performance limitation is the ability of the exoskeleton to recognize the intent of the operator so it can apply assistance to their desired motion. This intent recognition effort is typically solved using ad-hoc methods where subject matter experts make design decisions and tune transitions to identify intended maneuvers as re ...

Ultrasonic vocalizations (USVs) provide an excellent behavioral measure that can be used to understand the effects of traumatic stressors on behavior and can be used to screen and identify therapeutic treatments. This provides a strong justification for the use of rodent USVs as a model for emotional processing in PTSD. Since there are no commercially available USV assessment software programs tha ...

This proposal is to develop a Handoff Training for Combat Casualty Care (HTC3) Framework.Training is the crux of the handoff problem today. Patient handoffs are a crucial part of casualty care, both in military and civilian environments; and today handoffs are being performed in less than optimal fashion, with ineffective communications accounting for 80% of the handoff errors. Our new HTC3 Framew ...

In the setting of altitude-induced hypoxia, operator cognitive capacity degrades and can compromise both individual and team performance. This degradation is linked to falling brain energy (ATP) levels and an increased reliance on anaerobic energy production from glucose. Ketone bodies are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies have sho ...

Makel Engineering, Inc. and Sandia National Laboratories propose to demonstrate an advanced multi-modal sensor system suitable for in-situ analysis of exhaled VOCs for pilots, divers and field patients. Our proposed system will combine a micro-gas chromatograph (GC) and miniature ion mobility spectrometer (IMS) for detection of trace amounts of exhaled breath VOCs with miniature solid state sensor ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

BaySpec Inc., in collaboration with Pacific Northwest National Laboratory, proposes to develop an innovative orthogonal sensor systemthat would be able to detect, identify and quantify the inorganic components of breathing mixes, (i.e., nitrogen, oxygen, carbon dioxide, argon, helium, and water vapor), as well as individual detectable VOCs within the exhaled breath in real-time. The Phase I resear ...

LRT proposed to design a EMF detection system using future textile materials for combat uniforms. The sensor and signal processing design will be evaluated in phase I.