Award Data

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

The proposed approach provides innovative sensor data association algorithms capable of performing correct data association in multi-target tracking environments with one or more sensors. Current air and missile threats have the ability to fly non-ballistic, highly maneuvering hypersonic trajectories, and the ability to maintain closely spaced trajectories. Improved detection/track association is ...

At the core of the challenge facing MDA today is one of adversary air and missile threats being able to fly non-ballistic, highly maneuvering hypersonic trajectories all while having the capability of close formation flight of multiple missile threats. This problem results in challenges related to detection of the threat targets as well as the resulting filtering and data association problem. Ther ...

The objective of this project is to develop a capability to model fracture of materials used in hypersonic vehicles that results from hypervelocity impact while exposed to extreme temperatures. Symplectic Engineering’s approach addresses this challenge at two levels. At the computational level, a Relaxed Extended Finite Element approach is pursued to represent (possibly intersecting) fractures l ...

This STTR research study aims to enhance and apply thermo-mechanically coupled computational models for high-temperature fracture. This topic is particularly challenging in that hypersonic flight in the atmosphere generates extreme conditions over a vehicle that can affect the strength and performance the vehicle materials, both in-flight conditions as well as for cases where the vehicle encounter ...

At the Missile Defense Agency (MDA), the system-wide approach to test engineering generates massive amounts of multi-dimensional data, which analysts explore to evaluate Ballistic Missile Defense System (BMDS) configurations, engagement conditions, and target phenomena. Analyses are limited by time to construct each data query, technical knowledge, and size/complexity of the datasets and domain. T ...

This topic seeks an innovative NL solution for answering questions that data analysts ask when analyzing data sets to increase efficiency and consistency. The government is working on an all-digital missile defense simulation architecture that will deliver massive amounts of simulation data. Data analysts will soon be inundated with more data than they can possibly analyze manually. A critical par ...

The most direct way to meet the technical objectives for the Secure Virtual Environment (SVE) for Cyber Resiliency Validation would be to replicate the missile defense system’s tactical hardware, software, and network. However, this is cost prohibitive due to the amount of hardware procurement required for the Cyber test environment. Luckily, with the exception of supply chain threats, firmware, ...