Award Data

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

Assays for accurate diagnosis of early stages of infection with biothreat agents, on the day of infection or within a few days of infection, will find wide use in both civilian and military applications These diagnostic assays, which are anticipated to be highly specific and sensitive, will add to the repertoire of tools of hospitals and clinics that serve our armed forces personnel deployed on th ...

Sand particles ingested into aeroengines can impinge on components made of ceramic-matrix composites (CMCs) and cause structural damage including long-term erosion. Experimental analysis of erosion typically focuses on the damage footprint and mass loss and is limited in the range of operating parameters that can be examined. Hence, high-fidelity modeling of the erosion process is essential to der ...

A significant barrier to the insertion of ceramic matrix composite (CMC) materials into advanced aircraft engines is their inherent lack of toughness under erosion and post erosion. Our team will develop and demonstrate a physics-based model for erosion/post erosion of CMC’s at room and elevated temperatures (RT/ET). The ICME (Integrated Computational Material Engineering) Physics based Multi Sc ...

The objective of our proposed STTR phase-I work is to transition the latest advancements within the academic community to the design of a robust, user-friendly, and application-oriented tool for automatic hex-dominant meshing. Our software will fully couple CAD models to the discretized domain required by finite element software in structural analysis and other simulation and modeling applications ...

Advances in both software and computer hardware have made the finite element method the preeminent choice for analyzing highly complex systems that are of great value to the Department of Defense.   The US Defense industry, however, continues to spend enormous time and resources in mesh generation, a key step in finite element analysis, despite progress that has been made in automated mesh gener ...

The effective application of advanced simulation technologies is a critical component of the U.S. Navy’ efforts to meet current and future fleet needs. The application of some of these simulation technologies requires meshes that are mainly hexahedral, especially in critical areas. The current methods that can create the hexahedral element meshes best suited to accurate analysis by available sim ...

Improved propeller designs for Small Unmanned Aerial Systems are needed to improve performance and reduce acoustic emissions. Traditional propeller design methods don’t take advantage of advances in coupled fluid, structure and acoustics computational design methods nor advances in high strength, high modulus materials to extend performance of propellers and reduce noise emissions. In the propos ...