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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Advanced Assessment to Accelerate Diagnostic Skill Acquisition, Phase II

    SBC: Parallel Consulting, LLC            Topic: 300

    Project Summary Today s clinical learning environments do not provide the level of deliberate practicedirect supervisionand rigorous assessment and feedback needed to develop diagnostic reasoning expertiseClinical performance assessment emphasizes learner evaluation over learner developmentlacks rigor and utility for developmental purposesand clinical teachers have expressed particular difficulty ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. AFM based nanoscale IR Spectroscopy (AFM-IR) as a characterization platform for P

    SBC: Anasys Instruments Corp.            Topic: 300

    DESCRIPTION provided by applicant Anasys Instruments and Prof Lynne Taylor of Purdue propose to develop nanoscale chemical characterization capabilities for drug formulation research This project will build on successful Phase I research demonstrating feasibility of atomic force microscope based infrared spectroscopy AFM IR in pharmaceutical applications This Phase II research will advance ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Approach to Assessing Cognitive State During Real-World Tasks

    SBC: ADVANCED BRAIN MONITORING, INC.            Topic: 105

    DESCRIPTION provided by applicant In Phase our team was able to enhance the ABM B Alert system for use in on the road evaluations by reducing the overall profile of the hardware system introducing real time commenting for marking events in real world activities and assessing and confirming current artifact rejection algorithms for sufficiency in real world environments In addition the ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Assessment of the glucagon receptor blocker REMD-477 on insulin requirements in type 1 diabetes

    SBC: REMD BIOTHERAPEUTICS INC            Topic: NIDDK

    DESCRIPTIONprovided by applicantFast TrackInsulin remains the primaryand often the onlytreatment for typediabetes mellitusT DHowever it is associated with chronic iatrogenic hyperinsulinemiasecondary hyperlipidemiahigher incidence and severity of cardiovascular complicationsand life threatening hypoglycemia eventsA higher mortalityvsdue to cardiovascular complications were reported in insulin trea ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Augmenting Dual Energy CT for Novel Contrast Agents

    SBC: NEXTRAST, INC            Topic: 300

    Project SummaryAbstract Our long term goal is to revolutionize the effectiveness of CT imaging for millions of Americans across a broad range of abdominal diseaseDual energy CTDECTprovides powerful clinical diagnostic potential but remains heavily underutilized despite wide scanner availabilityDECT allows materials to be differentiated based on their relative X ray attenuation at low versus high e ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A user-friendly scalable microfluidic platform for enhanced neuron-cell culture

    SBC: Xona Microfluidics, Inc.            Topic: 101

    DESCRIPTIONprovided by applicantNeuron cell culture is widely used for studies in basic researchdrug discoveryand toxicity testingTraditional neuron cell culture approaches result in random growth of processes which prevent the study of their unique polarized morphologyOur goal is to provide robustuser friendlyand cost effective culture platforms to manipulate and access neurons and their subcellu ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Automated Image-based Biomarker Computation Tools for Diabetic Retinopathy

    SBC: EYENUK, INC.            Topic: NCATS

    DESCRIPTION provided by applicant In this STTR project we present EyeMark a set of advanced image analysis tools for automated computation of biomarkers for diabetic retinopathy DR using retinal fundus images Specifically we will develop tools for computation of microaneurysm MA appearance and disappearance rates jointly known as turnover rates for use as a biomarker in quantifying D ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. AutoRegister: A system for enhancing the accuracy of tumor change detection

    SBC: CORTICOMETRICS LLC            Topic: 102

    PROJECT SUMMARY This project proposes to continue the development of AutoRegisterTMan integrated software based system for enhancing the accuracy of tumor change detectionThe intent of the system is to automate the alignment of a patient s brain scan with that of a prior scan such that subsequent offline tumor measurements do not have error introduced solely by differing slice orientationsWhile si ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Bone targeted antimicrobials for biofilm-mediated osteolytic infection treatment

    SBC: BIOVINC, LLC            Topic: NIDCR

    ABSTRACT Dental implants are a central part of modern dental practice with the overall market for replacement and reconstruction of teeth expected to reach over $billion in the next several yearsIt is estimated that overmillion people in the United States are missing all of the teeth in one or both of their jaws leading to lower quality of lifeMost of these implants will be successful for long ter ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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