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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Maximizing cancer synthetic lethality using dual PI-3K/PARP inhibitors

    SBC: SignalRx Pharmaceuticals Inc.            Topic: NCI

    PARP inhibitors PARPi are particularly efficacious in tumors deficient in the BRCA tumor suppressor genes but of limited activity in BRCA competent tumors There is an unmet medical need to develop targeted therapeutic agents which will augment PARPi activity for BRCA wild type cancers and to increase chemo radiosensitivity in these malignancies BRCA proteins are essential components ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Target Identification for Novel Small Molecule Therapeutic for Alzheimer's disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Whole Brain Nanoscale Preservation Imaging

    SBC: Nectome Inc.            Topic: 101

    Abstract Summary Nectome will create technologies to enable whole brain nanoscale preservation and imaging a vital step towards a deep understanding of the mind and of the brainandapos s diseases Current brain processing technologies compromise between whole brain applicability or nanoscale resolution our technologies will achieve both si multaneously Similar to the way that next generation ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Memory Lane: A neuro-exergame to mitigate cognitive decline in later life

    SBC: 1ST PLAYABLE PRODUCTIONS LLC            Topic: NIA

    DESCRIPTION provided by applicant st Playable Productions and Union College propose to develop a commercializable product combining physical exercise and cognitive activities through interactive gaming on a stationary bicycle to help prevent cognitive decline and dementia in older adults The Interactive Physical and Cognitive Exercise System iPACES developed by Union Collegeandapos s Health ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. ARCHER- An Extremely Fast Medical Radiation Dose Computing Software

    SBC: VIRTUAL PHANTOMS INC            Topic: NIBIB

    DESCRIPTIONprovided by applicantThe goal of this project is to develop a commercial software package for rapid Monte Carlo based dose computation in imaging and radiation therapyThe product takes advantage of a desktop parallel computer equipped with emerging hardware originally developed gaming and high performance computingThe project is motivated by the fact that the market is ripe for a produc ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. An Agent-Based Modeling Platform for Environmental Biotechnology

    SBC: MICROVI BIOTECH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant Hazardous compounds in waters and soils are subject to a complex dynamic web of interactions among physical chemical and biological constituents in the natural environment Computational modeling has been proven indispensable to hazardous substances remediation particularly integrated modeling of pollutant hydrogeological fate and transport For the first t ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Expanding teleconsent capabilities to improve clinical research recruitment

    SBC: Doxy.me Inc.            Topic: NLM

    Lack of recruitment of qualified research participants into clinical trials remains to be one of the most important issues in clinical research Studies often struggle to meet recruitment goals on time resulting in costly time extensions underpowered results and in some cases early termination Many reasons attribute to suboptimal recruitment including the challenges related to informing and c ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Jamboxx: Interactive Respiratory Therapy through Music and Gaming

    SBC: My Music Machines Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The goal of this project is to develop a novel device for respiratory therapy that uses interactive gaming and music to encourage patient compliance In order to maintain pulmonary health many post operative surgery patients as well as people with quadriplegia and other spinal cord injuries high level motor neuron diseases such as amyotrophic lateral sclerosi ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Developing novel RPPA for the detection of metastatic prostate cancer

    SBC: Tymora Analytical Operations, LLC            Topic: 102

    PROJECT SUMMARY Reverse phase protein arrayRPPAhas emerged as a promising antibody based highly quantitative proteomic technology suitable for profiling proteins in hundreds to thousands of patient samplesThe throughputsensitivityand cost effectiveness of RPPAtogether with its ability to deal with minuscule sample amountshave propelled applications of the technology in basicpreclinical and clinica ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Real Time Oxygen Monitoring for Tissue Health Peripheral Artery Disease Application

    SBC: PROFUSA, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Continuous biochemical monitoring has the power to change currently accepted standards of care shifting the emphasis from treating illness to maintaining health Point in time snapshots of a patientandapos s health can miss critical fluctuations or early warning signs that might warrant early interventions or changes in disease treatment and management PROFUS ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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