Award Data

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

The broader/commercial impact of this Small Business Technology Transfer (STTR) Phase II project will focus on the preparation of new iron-based compounds as safer contrast agents for magnetic resonance imaging (MRI), an issue that particularly affects patients who have frequent MRI scans and those with chronic kidney disease. This project will advance the development of safer medical imaging. Thi ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to help find natural gas leaks to improve public safety and reduce natural gas rates. Natural gas leaks have led to fires and explosions that have injured hundreds of people, including some fatalities, and resulted in over $2 B in costs. By finding leaks before they become dangerous, improved detec ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase II project will enable collaboration with sensitive data. This will increase the ability of companies and institutions in sensitive domains, including biomedicine, to apply existing machine learning models and increase their ability to train new, more sophisticated models, thereby improving insights for ...

The broader impact of this Small Business Technology Transfer (STTR) Phase I project is in the use of aerogels in daylighting applications to efficiently incorporate natural lighting in building design, benefitting society by significantly decreasing energy consumption and simultaneously improving environments. Natural light is linked to health and productivity The daylighting market ascribes high ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project will be to develop a highly sensitive assay that characterizes protein modifications for life science research applications. Proteins are life's nanomachines and serve as the targets for almost all drugs and the vast majority of diagnostic tests. One type of Modifications to proteins, such as ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to reduce the cost of surgical operations. Instrument tracking enables hospitals to optimize the supply chain, with a potential annual benefit to the US healthcare system of $8.5 B. Predictive scheduling can save $500k per operating room (OR) by closing gap times between procedures. Similar ...

The broader impact of this Small Business Technology Transfer (STTR) Phase I project will be an affordable, portable breath analysis device to detect marijuana intoxication. First responders, law enforcement, medical professionals, cannabis users, and the general public will benefit from an analytical tool that allows fast and accurate screenings of cannabis impairment. An estimated 37,000 people ...