Award Data

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Marburg virus (MARV) is a filamentous enveloped non-segmented negative sense RNA virus. This viruse is considered to be extremelydangerous with case fatality rates as high as 88-90%. Extensive efforts have gone towards effective vaccines for MARV prevention, however,none have been successfully established as licensed vaccines. Glycoprotein (GP) is the only surface protein of MARV. There are substa ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

NanoSonic has recently developed a hydrogen (H2) dispenser hose to realize H2 as a safe, reliable, and cost competitive replacement for gasoline. NanoSonic's ultra-low glass transition temperature (Tg of -100 ?C) is expected to meet the service requirement of 25,550 fills/year (70 fills/day for 2 years) at a combined ultra-high pressure of 875-bar and very wide service temperature range of -50?C ...

This NASA Phase I SBIR program would fabricate wireless networked nanomembrane (NM) based surface pressure sensors for remote monitoring in propulsion systems, using SOI (Silicon on Insulator) NM techniques in combination with our pioneering HybridSil ceramic nanocomposite materials. Such low-modulus, conformal nanomembrane sensor skins with integrated interconnect elements and electronic devices ...

PC Krause and Associates is partnering with Purdue University, EleQuant, and GridQuant to create a hybrid modeling capability. The combination of PCKA?s extensive dynamic modeling experience, Purdue?s work in electromechanical systems analysis, and GridQuant and Elequant?s development of the HELM algorithm uniquely positions the team to create this technology. HELM is a novel algorithm that solves ...

Through the proposed STTR program, NanoSonic and Virginia Tech will create an innovative low viscosity, high Tg copolymer injection repair material and methodology that enables fiber reinforced composite repair within a short time frame in areas with limited user access. The proposed injection repair material will consist of fluidic HybridSil poly(siloxane imide) resins that are molecularly engine ...

To provide additional telemetry and data for long-term mission, the composition of internal atmosphere of spacesuits must be determined. Specifically, the unambiguous detection and quantification of carbon dioxide is crucial for mission completion. Detection of other gasses (ammonia, oxygen) is also necessary for a complete sensor suite. Seacoast Science and Case Western Reserve University pro ...

Future long-duration, crewed space habitat systems will be inflatable structures. This type of structure is advantageous in that it is not limited to the diameter of the launch vehicle and can therefore provide a greater volume of living and work space. Unlike conventional metal structures, however, softbody inflatables require support members to maintain their desired shapes. Despite their robust ...

NASA has been investigating morphing aircraft for multi-mission capabilities and performance improvements in existing fixed-wing aircraft. In addition, the design of aeroelastic aircraft that can control the structural flexibility to their advantage, is an open area of research and development. In spite of the plethora of work on morphing aircraft and long slender wings, the goal of fielding such ...