Award Data

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Marburg virus (MARV) is a filamentous enveloped non-segmented negative sense RNA virus. This viruse is considered to be extremelydangerous with case fatality rates as high as 88-90%. Extensive efforts have gone towards effective vaccines for MARV prevention, however,none have been successfully established as licensed vaccines. Glycoprotein (GP) is the only surface protein of MARV. There are substa ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

This Air Force Phase I STTR program would develop self-calibrating, conformal nanomembrane (NM) based pressure sensors for embedded sensing applications, using SOI (Silicon on Insulator) NM techniques in combination with our pioneering nanocomposite materials.Such low-modulus, conformal nanomembrane sensor skins with integrated self-calibration, interconnect elements and electronic devices that ca ...

The main objective of this STTR Phase I effort is two-fold. First, to develop a robust approach for coupling the flow solver Kestrel with the multidisciplinary software tool AERO Suite in order to enable the physics-based modeling and simulation of the dynamics of Aerodynamics Decelerator Systems (ADS) such as parachutes from deployment to terminal velocity or terminal descent and touchdown, and t ...

The development and implementation of new damage morphology models for concrete materials is critical to understanding their dynamic behavior during severe shock loading environments.Current constitutive models of conventional strength concretes do not accurately represent the behavioral characteristics of new ultra-high strength concretes because of differences in damage mechanisms during failure ...

This SBIR Phase I project proposes a visual processing system for automated target recognition. Inspired by biological vision systems and hierarchical memory models, the proposed system is capable of learning hierarchical invariant features from unlabeled data that are independent of object labels. The model exploits these learned features to create hierarchical representations of target memories ...

Previous research indicates the digital holography (DH) methods when combined with model-based iterative reconstruction can solve the challenging problems posed by the need to image through deep turbulence real time. In this Phase I STTR research, we propose to analyze and design a high-performance computing system and associated Deep-turbulence Estimator for Anisoplanatic Propogation (DEAP) algor ...

The Department of Defense relies on a worldwide network of radar and optical sites to maintain Space Situational Awareness.Although careful consideration during site selection process solves some of this mission's challenges, optical sensor imaging of objects at significant ranges is always hampered by many other factors, such as limited-aperture optics and atmospheric turbulence.There remains, ho ...

The objective of this program is to develop, demonstrate and implement a low reconfigurable, reliable Free Space Optical (FSO) link supporting high bandwidth communications for satellite to satellite or satellite to ground communication. The FSO Transceiver (Transmitter/Receiver) to be implemented will be small Size, Weight, Power and Cost (SWaP-C) such that it can be easily carried by compact spa ...