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DESCRIPTION (provided by applicant): There is a national need for conflict resolution and peace education. Skit-based performances and open discussion are two frequently successful methods of working with children to develop conflict resolution skills. This project is creating a core set of conflict resolution modules along with ongoing new video-scenarios and educational materials that explore va ...

DESCRIPTION (provided by applicant): There is a national need for conflict resolution and peace education. Skit-based performances and open discussion are two frequently successful methods of working with children to develop conflict resolution skills. This project is creating a core set of conflict resolution modules along with ongoing new video-scenarios and educational materials that explore va ...

Electrocardiogram is the most common cardiac examination ordered by physicians. In the past, only persons working in the ECG laboratory were allowed to perform a 12-lead ECG on a patient. Today, however, this task has been delegated to a variety of health professionals, including registered nurses, licensed practical nurses, and even nursing assistants in some health care facilities. There is a ne ...

completion, the entire course will provide a professional certificate with continuing nursing education contact hours or can be transferred as academic credit in an undergraduate-nursing program. The model for the OCPP to be developed in this project has three components: didactic core content, clinical practicum, and a Virtual Center of Best Practices. The core ...

DESCRIPTION (provided by applicant): DNA damages are key events during carcinogenesis. Deficiencies in repairing damaged DNA represent a poor prognosis during tumorigenesis and/or cancer treatment. Besides monitoring DNA damage formation, it would be helpful to monitor DNA repair protein activity. We propose to develop a new technology that allows for high-throughput and fast analysis of the most ...

DESCRIPTION (provided by applicant): The aim of this proposal is to develop a series of fluorogenic imaging molecules, which can be easily delivered into viable cells and monitor cellular functions. The FIMs are composed of a peptide backbone containing a target site for a kinase or a protease. Some designs borrow from the molecular beacon approach and carry flurophore/quencher moieties, while oth ...

DESCRIPTION (provided by applicant): This proposal focuses on the development of multi-well ELISA-like assays to quantify DNA binding activity of two breast cancer prognosis markers, Sp1 and ER, with much more sensitivity and high throughput than standard DNA gel shift techniques. Such an approach has already been successfully applied to monitoring transcription factor activation by Active Motif ...

Alzheimer's disease (AD) is a debilitating mental disorder that results in a progressive loss of cognitive functions. However, there is no effective treatment for this disease. The neurotoxin AB peptide plays a central role in AD, involving increased production and accumulation of AB in brain amyloid plaques. Proteolytic processing of the amyloid precursor protein (APP) is required to generate AB, ...