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A Rapid Paper Strip Nucleic Acid Test for the Point of Care Detection of Zika virus CrossLife Technologies Inc Project Summary Abstract There are unmet needs for nucleic acids new diagnostics that can be applied at the point of care to detect Zika Virus ZIKV infections A highly sensitive simple paper strip molecular test that detects ZIKV at the point of care will be developed The target seq ...

Project Summary Monoclonal antibodies mAbs are a well validated drug platform with exquisite specificity diversity and potency They offer the lowest risk class of drug for development through licensure and offer great potential for addressing emerging and re emerging infectious diseases To be prepared as threats like Ebola EBOV Marburg MARV and Zika viruses continue to emerge or re em ...

Immune mediated diseases such as type diabetes T D multiple sclerosis rheumatoid arthritis and systemic lupus erythematosis are reaching epidemic proportions in the US T D affects an estimated million Americans with more than new patients diagnosed annually resulting in roughly $ B in health care costs in the US each year T D is an autoimmune disease characterized by effector ...

The proposed project aims to build a diagnostic test for chronic T cruzi infection and Chagas disease that not only improves testing performance but that can be readily integrated with similarly developed tests for most clinically important parasitoses Current assays for Chagas disease and other parasitic infections lack desired levels of specificity and require multiple independent assays an ...

Human rhinovirus RV is the predominant etiological agent of the common cold and the leading cause of human infectious disease RV is more than a nuisance It is a major cause of community acquired pneumonia in children and adults in the United States and plays a major role in triggering exacerbations of both asthma and chronic obstructive pulmonary disease resulting in billions of dollars in me ...

PROJECT SUMMARY ABSTRACT Members of the Candida genus of fungi form part of the normal human microbiota but are also opportunistic pathogens capable of causing serious mucosal and systemic infectionsCandida cells grow and divide in suspensionplanktonicculturesbut they also form resilient and drug resistant biofilmsorganizedtightlypacked communities of cells attached to a surfaceBiofilms colonize m ...

ABSTRACT This program aims to develop a method for banking clinical grade bone marrow from cadaveric donors that can be deployed nationally to ameliorate shortages provide bone marrow stockpiles as medical countermeasures for nuclear threats and support existing research approaches such as delayed immune tolerance induction and transfusion of HIV resistant stem cells We will adapt a method de ...

PROJECT SUMMARY The Dengue DENV and Chikungunya viruses CHIKV are primarily transmitted by two types of mosquitoes the Aedes aegypti and the Aedes albopictus Patients infected by DENV may experience dengue fever dengue hemorrhagic fever DHF and dengue shock syndrome DSS DHF and DSS could be fatal and are of particular public health concern in endemic regions of the U S Africa Asia ...

ABSTRACTTechnology to deliveron demandmolecules that bind targets or catalyze reactions of choice has been a goal of chemistry foryearsEven todaytheory is inadequate to support de novo design of receptors having useful affinity or catalysts having useful turnoverThusmany have sought to create those catalysts on a DNA or RNAcollectivelyxNAusing the Darwinism to these biomolecules to evolveunder lab ...

DESCRIPTION provided by applicant Middle East Respiratory Syndrome MERS coronavirus MERS CoV causes severe acute respiratory illness with a high fatality rate among reported cases MERS was first reported in but the virus has been circulating in camels which are thought to be an animal reservoir for at least years To date over MERS cases have been reported to the World Hea ...