Award Data

_x000D_Currently available biomass heating/cooking stoves in Asia and in the USA do not efficiently cook food or heat houses while consuming too much fuel and emitting pollution, resulting in respiratory illnesses and premature death. ASAT specializes in the development and manufacturing of clean burning biomass stoves. In SBIR Phase I, ASAT developed a low emission, fuel efficient Integrated Heat ...

Project Summary Diabetic retinopathy DR is a leading cause of vision loss affecting about million people worldwide A major breakthrough in DR therapy is the recent approval of vascular endothelial growth factor VEGF inhibitors However anti VEGF therapy has limited efficacy with a number of side effects The critical barrier is how to identify other angiogenic targets for alternative or ...

The metabolic syndrome MetS is a cluster of factors that increases the risks for cardiovascular disease type diabetes mellitus and mortality and currently affects andgt of US adults MetS is associated with endothelial dysfunction decreased circulating endothelial progenitor cells EPCs and a pro inflammatory state We have made the exciting discovery that therapy with allogeneic me ...

ABSTRACT Traditional mon therapeutictarget driven approaches to drug development for Alzheimer s diseaseADare becoming increasingly expensive and in many cases disappointingly unsuccessfulBased on preliminary in vitro and in vivo studies we have identified a novel small moleculemethyldimethyloxodihydrobenzo cnaphthyridinecarboxylateBNCthat significantly decreases neuroinflammation and production o ...

Technical AbstractAs with many chemotherapeutic drugstaxanes exhibit poor oral bioavailabilityhencethey are administered intravenouslyi vThis regimen results in significant toxicitiesdue to both the high drug dose and vehicleCremophore ELRusedAttempts made to develop an oral chemotherapeuticusing liposomes and polymeric nanoparticles as carriershave not made it to the clinicdue to their inherent l ...

PROJECT SUMMARY ABSTRACT STEM Familia A language acquisition mobile app to improve long term educational and health outcomes among Latino families Enhancing the STEM science technology engineering and math proficiency of Hispanic elementary students to prepare them for success in secondary school and college STEM courses and in STEM fields after graduation While STEM fields account for mo ...

ABSTRACT The proposed intervention Culturally Responsible Stress Reduction A Mobile Mindfulness Application to Support Health Promotion for African Americans CRSR is designed to encourage the use of mindfulness to mitigate the disproportionate amount of stress related health disparities facing African Americans Current mindfulness approaches have been unsuccessful in engaging this popula ...

Errors in the planning and delivery of radiation therapy can result in inferior outcomes for patients The magnitude of this problem is now well appreciated from cooperative group trials and other sources At present however there are few concrete tools to reduce the chance of plan errors passing undetected Current practice uses a variety of error mitigation means such as human inspection of th ...

ABSTRACT Simple protein mutations can have serious consequences by causing diseases that affect peopleandapos s lives Protein therapeutics are developed to target and replace those protein mutations and essentially to heal the disease Distinctively membrane proteins make up over of todayandapos s drug targets However cumbersome time consuming and often ineffectual purification methods ...

Personal behaviors during pregnancy influence gestational weight gain gestational diabetes mellitus and preeclampsia in addition to developmental programming of the offspring This application is designed to assess the technical merit feasibility usability and potential commercial application of a digital platform and wellness curriculum to reduce the health risks of the mother and child durin ...