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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Biocatalytic Route to Nitrile Reduction

    SBC: QUZYME, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The recently identified ykvM gene family encodes an enzyme belonging to a unique family of nitrile oxido-reductases that catalyze the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine, a transformation never before observed in biology. Nitrile containing compounds are ubiquitous in the pharmaceutical, agricultural, and chemical industries, wh ...

    SBIR Phase I 2006 Department of Health and Human Services
  2. A Cognitive-Behavioral Multimedia Internet Program to Prevent Youth Depression

    SBC: Oregon Center For Applied Science, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Depression is one of the most prevalent mental disorders to afflict adolescents. It seriously impacts role functioning and typically takes a recurrent or chronic course. Because most depressed youth never receive treatment, there is a critical need to develop effective prevention programs that can be easily implemented and widely disseminated. The proposed proj ...

    SBIR Phase II 2006 Department of Health and Human Services
  3. A computational platform to prioritize drugs and target genes for therapeutic intervention

    SBC: Genetic Networks, LLC            Topic: NCATS

    Project Summary This project proposes implementation of a computational discovery platform that quantifiably identifies and prioritizes both targets and compounds for therapeutic intervention This platform is based on a novel fusion of two state of the art computational approaches phenolog mapping and functional networks with proprietary data from our powerful gene drug screening assays HIP H ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A counterpulsation device to promote myocardial recovery

    SBC: SCR, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The incidence of congestive heart failure (CHF) is increasing worldwide with over one million new cases diagnosed annually. Over the past 30 years, counterpulsation with an intra-aortic balloon pump (IABP) has been widely and successfully used as a short-term treatment for cardiac dysfunction. However, counterpulsation is limited by its location within the desc ...

    SBIR Phase I 2006 Department of Health and Human Services
  5. A Cytomegalovirus based therapeutic vaccine for chronic hepatitis B

    SBC: TOMEGAVAX, INC.            Topic: R

    Abstract Although an efficient prophylactic vaccine is available for hepatitis B virus HBV chronic hepatitis B CHB affects up to million people worldwide and despite advances remains mostly incurable In adults acute HBV infection is cleared in of cases by CD T cell mediated mechanisms but chronic lifelong infection ensues in the remaining individuals which can lead to liver ci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Hidden Markov Model Based Segmentation Framework for MR Spectroscopy Imaging

    SBC: INFOTECH SOFT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The convergence of biomedicine and computation in the form of biomedical computing has demonstrated gains in the areas of genetic sequences, biomedical images, qualitative descriptors for health and social science and geospatial images and chemical formulae. This provides a unique opportunity to utilize novel image processing techniques to more accurately and o ...

    STTR Phase I 2006 Department of Health and Human Services
  7. A Hidden Markov Model Based Segmentation Framework for MR Spectroscopy Imaging

    SBC: INFOTECH SOFT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The convergence of biomedicine and computation in the form of biomedical computing has demonstrated gains in the areas of genetic sequences, biomedical images, qualitative descriptors for health and social science and geospatial images and chemical formulae. This provides a unique opportunity to utilize novel image processing techniques to more accurately and o ...

    SBIR Phase I 2006 Department of Health and Human Services
  8. A High Throughput System for Multichannel Neurophysiology

    SBC: TUCKER-DAVIS TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent technical developments have made simultaneously recording the activity of many neurons possible. These experiments show great promise in both basic and applied research, illustrating the dynamic interplay between large populations of neurons as well as the potential for neuroprosthetic control of artificial limbs or restoring sensory input. To support th ...

    SBIR Phase I 2006 Department of Health and Human Services
  9. A mobile framework to measure ejection fraction by automated non-invasive analysis of cardiac signals

    SBC: AVENTUSOFT L.L.C.            Topic: 102

    PROJECT SUMMARY ABSTRACT This SBIR Phase II project will develop a novel mobile framework to measure left ventricular ejection fraction as a marker for systolic dysfunction using automated non invasive analysis of cardiac signalsHeart disease is the leading cause of death for men and women accounting for more than one thirdof all U SdeathsIntotal costs associated with cardiovascular disease in the ...

    SBIR Phase II 2017 Department of Health and Human Services
  10. A Non invasive Assay for Obstructive Sleep Apnea

    SBC: PGXL TECHNOLOGIES, LLC            Topic: NHLBI

    Project Abstract PGXL Technologies is developing novel urine based tests for detecting obstructive sleep apnea OSA in children Obstructive sleep apnea OSA is a disorder giving rise to behavioral and learning problems including misdiagnoses as attention deficit hyperactivity disorder ADHD in children The CDC estimates the prevalence of pediatric OSA in the US at around million An ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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