Award Data

ABSTRACT Human prion diseases are infectious and invariably fatal neurodegenerative diseases including sporadic Creutzfeldt Jakob disease sCJD the most common form and variant CJD vCJD which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy Currently there is not sensitive objective and non invasive biochemical diagnosis for these diseases and even ...

DESCRIPTION provided by applicant The Fontan procedure or total cavopulmonary connection TCPC is a standard palliative surgery for patients with complex single ventricle congenital heart anomalies TCPC connects the inferior and superior vena cava IVC and SVC directly to the right pulmonary artery bypassing the heart The single ventricle is then reserved for pumping oxygenated blood to th ...

Native American Cancer Initiatives Inc NACI is a woman owned minority American Indian business with fewer than three full time equivalent employees This for profit company founded in has the mission to provide technical assistance and products to communities patients researchers academicians universities research institutions and professionals on Native Americans cultural iss ...

Project Summary The long term goal of this project is to develop validate and commercialize an assay for improved analysis of C orf a gene on chromosome that is linked to frontotemporal dementia FTD and amyotrophic lateral sclerosis ALS Expansion of a guanine and cytosine rich hexanucleotide repeat GGGGCC in the non coding region of C orf is associated with of familial ALS Th ...

Despite the recent development of novel therapeutic approaches no curative treatment is available for advanced stage melanoma with year survival below Targeted therapy is one of the most promising therapeutic strategies to the treatment of cancer and is a key component of precision medicine which aims to individualize cancer treatment for a given patient IL RA an oncogenic isoform o ...

Boulder Nonlinear Systems BNS and Prof Edward Boyden s Synthetic Neurobiology Group at the Massachusetts Institute of Technology MIT Media Lab propose to develop a new liquid crystal spatial light modulator SLM capable generating high resolution holograms to overcome the imaging gap that currently divides cellular level optogenetic techniques and whole brain techniques to improve function ...

Abstract Peripheral artery disease PAD is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs thereby restricting blood flow During exercise or simply walking there is not sufficient blood flow to keep up with the metabolic demand This causes symptoms most notably leg pain when walking intermittent claudication PAD is also likely to be a sign of more w ...

ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

Manufacturing of Portland cement, the primary binder in concrete, accounts for ~7% of global CO2 emissions, 4% of energy use, and exhaustion of natural resources. Premature aging of concrete in infrastructure systems is another major concern.  A robust binder chemistry has been developed to overcome these drawbacks.  The original approach to production of this binder, however, is not compatible ...

Fumed silica is an important additive in many products including paints, plastics and tires, but it is produced by an energy-intensive costly, toxic and hazardous process. SioTex has developed a superior triple green replacement for fumed silica that produces no toxic waste, uses little energy, and is inexpensive.  Our patent pending technology uses rice hulls, a bio-waste, as the feedstock.  Us ...