Award Data

Acute exposure to mycotoxins can lead to systemic toxicity and even death. With no specific treatment available, aflatoxin and trichothecene T-2toxin, in particular, are of concern as potential biological weapons due to their toxicity, thermal and UV stability and easy accessibility. As amedical countermeasure, we propose the development of highly porous polymer beads optimized for removal of afla ...

Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is rel

Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...

Teachley Connect will be a mobile tablet-based platform that uses games to give elementary schools rich formative assessment data and intervention support. Teachley Connect will permit students to continue playing exactly where they left off on any tablet. The platform will also connect apps into a single teacher dashboard, providing teachers detailed reports on student performance across games, w ...

Due to their exceptional properties, polyurethane coatings are used extensively in our society.Unfortunately, the socyanate-functional components used in the curing of polyurethanes are generally toxic. Thus, there is a need for polyurethane resins that can be cured without the use of isocyanate-functional components. In addition to enabling the production of polyurethane coatings that are free ...

Electronic Waste is the fastest growing waste stream in the US. Significant amounts are recoverable for reuse, resale, and refining for precious metals. The disassemblers send circuit boards to refiners/smelters for precious metals recovery. E-Waste disassemblers remove parts from these circuit boards, so only certain parts are smelted. As such they are the key market for our depopulator. Refiners ...

Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...

Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometric measurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed software app aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D im ...

The objective of the proposed Phase II project is to develop a hand-held, rapid plasmonic biosensor -- a detector based upon surfaceplasmon resonances (SPR) that incorporates a new class of supercharged proteins that functionalize a low-cost, disposable plasmonicchip. Each protein is designed to bind to a pre-determined toxin with high specificity. Upon successful binding, the protein superfoldsre ...