Award Data

Project Summary In the NIDA SBIR Phase I project, Arborsense will develop a portable sweat-based screening device for rapid, non-invasive, point-of-need, and quantitative detection of drugs of abuse. The use and abuse of potentially- addictive substances has become a national crisis with immense social (~93,000 deaths in 2020) and economic costs (~$400B annually). Consequently, regular drug-use te ...

ABSTRACT More than 3 million tests are performed each year to support the laboratory diagnosis of human Lyme disease (LD). While the CDC conventional standard two-tier (CSTT) approach for serodiagnosis of LD has worked relatively well when used as recommended, there is plenty of room for improvement. Of a number of weaknesses associated with the supplemental immunoblot of the CSTT the most signifi ...

Experiad will develop a new type of parent engagement platform, called Goalspace, which will facilitate parent- assisted Applied Behavior Analysis (ABA). Goalspace has the potential to have a major impact on autism treatment worldwide by increasing the amount of parent engagement in ABA therapy. Demand for ABA services far exceeds capacity. Parent-assisted ABA is a key evidence-based component of ...

ABSTRACT Atrial Fibrillation (AF) is characterized by a disorganized activation of the atrium leading to impaired cardiac function and more serious complications like embolic stroke, worsening heart failure, and increased mortality. AE affects 9% of the U.S. population (2% younger than 65) and contributes to 750,000 hospitalizations and 130,000 deaths per year. There is a clear unmet clinical need ...

PROJECT SUMMARY/ABSTRACT The purpose of this project is to evaluate the effectiveness of GratePic, a mobile health (mHealth) application dedicated to helping users enhance gratitude. A large body of empirical research indicates a strong association between gratitude and psychological well-being, to include: reduction in depressive symptoms, a decrease in suicidal ideations, an increased sense of m ...

PROJECT SUMMARY/ABSTRACT Peripheral artery disease (PAD) affects nearly 12 million people in the United States. One of the most common surgical therapies is peripheral artery bypass grafting (PABG). Some patients are eligible for less invasive treatment options like angioplasty, but patients with calcified lesions are not. In patients that do receive PABG, approximately 20% fail within the first y ...

Project Summary Globally, low breastfeeding rates account for nearly a million annual preventable deaths of women and children. Suboptimal breastfeeding in the United States is associated with $18B in healthcare costs and 3,340 annual premature deaths of women and children. Lack of support from healthcare providers is a primary reason for low breastfeeding rates. Physicians and nurses receive inad ...

Project Summary Abstract Nymirum will utilize its technology platform to identify and optimize a drug-like, orally available small molecule that binds toxic CUG repeat RNAs to rescue myotonic dystrophy type 1 (DM1) derived mis-splicing and treat the disease. DM1 is a rare genetic disorder that leads to progressive muscle degeneration, cardiovascular disease, severe cognitive disabilities, insulin ...

ABSTRACT: Cutaneous vascular malformations (CVM), such as port wine stain (PWS) which occurs in 0.3–0.5% of newborns, are often a cause of great concern to patients for both medical and cosmetic reasons. Laser irradiation with flashlamp-pumped pulsed dye lasers, i.e. photothermolysis therapy (PTT), is currently the gold standard treatment for PWS. Most patients with PWS, however, fail to clear c ...

Project Summary/Abstract Positron emission tomography (PET) is an exquisitely sensitive and quantitative imaging modality with numerous applications in oncology, neuroimaging, infection/inflammation, and cardiology. PET has great potential for hybrid imaging techniques in which nuclear medicine can be combined with anatomic imaging techniques such as magnetic resonance imaging (MRI). Such approach ...