Award Data

THE MAIN OBJECTIVE OF THIS PHASE I PROJECT WAS TO ESTABLISH A SOURCE OF SERUM-FREE MEDIUM SUITABLE FOR SUSTAINED GROWTH OF EARLY PASSAGE SYRIAN HAMSTER EMBRYO (SHE) CELLS. SPECIFIC AIMS INCLUDED SELECTION OF A BASAL MEDIUM SUPPORTIVE OF CLONAL GROWTH IN LIMITING SERUM CONCENTRATIONS, REPLACEMENT OF SERUM BY SELECTED GROWTH FACTORS AND HORMONES, OPTIMIZATION OF SUPPLEMENTS BY CLONAL TITRATIONS, AND ...

UNTIL NOW, THE BENEFITS OF COMPUTERIZATION HAVE NOT SPREAD TO IMAGE-BASED FIELDS SUCH AS PATHOLOGY. ALTHOUGH A FEW EXPENSIVE IMAGE-PROCESSING COMPUTER SYSTEMS HAVE BEEN USED FOR PATHOLOGY RESEARCH, AFFORDABLE, GENERAL-PURPOSE SYSTEMS HAVE BEEN UNAVAILABLE. IMAGE PROCESSING HAS BEEN LIMITED TO BLACK-AND-WHITE IMAGES. RECENT PROGRESS IN MICROCOMPUTERIMAGE-PROCESSING HARDWARE WILL NOW ALLOW THE PRODU ...

THE BROAD GOAL OF THIS PROJECT IS TO DEVELOP AN EVALUATION SYSTEM THAT IDENTIFIES, CATALOGS, AND ASSESSES THE QUALITY OF MATERIALS DESIGNED FOR USE IN WORKSITE HEALTH PROMOTION PROGRAMS IN THE AREAS OF NUTRITION AND WEIGHT LOSS, SMOKING CESSATION, AND CANCER SCREENING. SPECIFIC OBJECTIVES OF PHASE I INCLUDE: (1) CONDUCTING A NEEDS ASSESSMENT; (2) IDENTIFYING AND COLLECTING WORKSITE MATERIALS ON NU ...

THE PURPOSE OF THE PROPOSED RESEARCH AND DEVELOPMENT EFFORT IS TO DEVELOP A LOW COST/GENERAL PURPOSE ACR-NEMA PACS INTERFACE. THE LONG TERM GOAL OF THIS EFFORT IS THE DEVELOPMENT OF AN APPLICATION SPECIFIC INTEGRATED CIRCUIT (ASIC) IMPLEMENTATION OF THE ACR-NEMA INTERFACE STANDARD. THIS ASIC WOULD CONTAIN THE INTERFACE TRANSCEIVERS AND THE LOGIC TO IMPLEMENT THE PHYSICAL AND DATALINK LAYERS OF THE ...

CHROMIUM DEFICIENCY CAUSES SEVERE INSULIN RESISTANCE AND GLUCOSE INTOLERANCE. AVERAGE DIETARY CHROMIUM INTAKE IN THEUNITED STATES AND OTHER DEVELOPED COUNTRIES IS MARGINAL AND MAY CONTRIBUTE TO THE HIGH FREQUENCY OF DIABETES PLAGUING DEVELOPED COUNTRIES. THE MAJOR CLINICAL CHROMIUM EVALUATIONPROBLEM IS THE ASSESSMENT OF CHROMIUM STATUS. DETERMINATIONOF CHROMIUM STATUS HAS BEEN DIFFICULT BECAUSE OF ...

THIS PROPOSAL DEALS WITH THE DEVELOPMENT OF A RADIATION DETECTOR TO MAKE POSSIBLE THE DIRECT MEASURMENT OF THE STRUCTURE OF CHARGED-PARTICLE TRACKS IN A GAS. SUCH A DETECTOR WILL PERMIT THE MEASUREMENT OF MICRODOSIMETRIC DISTRIBUTIONS IN VOLUMES THAT CORRESPOND TO NANOMETERS IN A BIOLOGICAL CELL, E.G., THE DIAMETER OF A DNA MOLECULE. WHENA CHARGED PARTICLE PENETRATES A GAS, ELECTRONS PRODUCED DURI ...

THE GOAL OF THIS PHASE I EFFORT IS TO DEVELOP AND VALIDATE A CAPABILITY FOR QUANTITATIVE ANALYSIS AND DISPLAY OF CT, MRI, AND ECT IMAGES OF THE BRAIN. WE PROPOSE TO DEVELOP AND VALIDATE THE OVERALL APPROACH OF MULTI-MODAL IMAGE REGISTRATION AND DISPLAY OF THE IMAGES, FILTERING OF ECT DATA TO SIMULTANEOUSLY ENHANCE RESOLUTION AND REDUCE NOISE, AND TECHNIQUES TO GENERATE PRECISE QUANTITATION OF TWO ...

THE RESEARCH PROPOSED IS TO INVESTIGATE THE FEASIBILITY OF WRITING A SOFTWARE PACKAGE FOR PERSONAL WORKSTATIONS THAT WILL HELP CLINICAL RESEARCHERS AND THEIR ASSISTANTS CARRY OUT THE DESIGN, DATA COLLECTION, DATA STORAGE, AND FORMAL AND EXPLORATORY ANALYSES OF CLINICAL TRIALS. THE PURPOSE OF SUCH SOFTWARE WILL BE TO ASSIST THE SINGLE RESEARCHER OR THE SMALL GROUP DOING SMALL- TO MODERATE-SIZED TRI ...

HEPATITIS B VIRUS (HBV) IS A MAJOR HUMAN PATHOGEN WHICH INFECTS APPROXIMATELY 200 MILLION INDIVIDUALS WORLDWIDE AND CAUSES PROGRESSIVE LIVER DAMAGE, CIRRHOSIS AND PRIMARY HEPATOCELLULAR CARCINOMA. VACCINATION OFFERS A MEANS FOR DISEASE PREVENTION BUT THERE REMAINS AN IMMEDIATE NEED TO TREAT THOSE WHO ARE CHRONICALLY INFECTED. THE IDENTIFICATION OF NEW ANTIVIRAL AGENTS TO TREAT HBV-INFECTEDINDIVIDU ...

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A RAPID, SPECIFIC, COST-EFFECTIVE TEST FOR HUMAN ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS (HIV) ANTIGENS UTILIZING A NOVEL CAPACITIVE AFFINITY SENSOR TECHNOLOGY. THE SPECIFIC AIMS OF THIS RESEARCH ARE: 1) TO EVALUATE METHODS BY WHICH HIV ANTIGENS FROM VIRAL PROTEINS GP41 AND P24 CAN BE IMMOBILIZED ON THE SURFACE OF THE BIOSENSOR AND 2) TO DE ...