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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Extended Release of Pyridostigmine Bromide for Effectively Combating Nerve Agent Exposure

    SBC: Innosense Llc            Topic: CBD181004

    Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigminebromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it actsas a temporary inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitigating th ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  2. Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

    SBC: Zymeron Corporation            Topic: CBD181004

    Given the unforeseen/unanticipated use of nerve agents in the battlefield and on the homeland, military personnel can benefit from this oncedaily pretreatment. It may also be desirable to pretreat certain medical and emergency aid personnel following a known/suspected nerveagent attack. Also, a novel, improved PB extended release formulations can be commercialized for the treatment of myasthenia g ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  3. Stable Formulation of Nerve Agent Intoxication Countermeasures

    SBC: Luna Innovations Incorporated            Topic: CBD181005

    In response to the defined need for minimizing the carry weight of combat teams while retaining capability, Luna Innovations is proposing thedevelopment of a stable formulation of atropine and scopolamine for use in an autoinjector to combat nerve agent intoxication. Thecombined formulation of atropine and scopolamine will allow for better treatment with more physiological coverage within the huma ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  4. Dual Formulation of Atropine and Scopolamine with Enhanced Stability

    SBC: Nano Terra, Inc.            Topic: CBD181005

    The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survivalrates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ca ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  5. Dual Formulation of Atropine/Scopolamine with Enhanced Stability

    SBC: Cmc Pharmaceuticals, Inc.            Topic: CBD181005

    CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as acounter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacologicalprofiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. It ...

    SBIR Phase I 2019 Department of DefenseOffice for Chemical and Biological Defense
  6. Tomographic Nanoscopy for Pathogen Identification

    SBC: SOLID STATE SCIENTIFIC CORPORATION            Topic: CBD171003

    This effort will augment the capabilities of an existing all reflecting, confocal FTIR microscope to allow for digital holographic imaging as wellspectral content determination at video frame rates. The use of a dual beam frequency comb, with a beam path coincident with the pathrequired for the digital holographic imaging, will allow spectral determination of any organism being holographically ima ...

    SBIR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  7. Process Development and Manufacture of an Antibody-based Therapy Against Sudan EbolaVirus

    SBC: BIOFACTURA, INC.            Topic: CBD171005

    Recently we have observed a massive outbreak of Ebola virus. This family of virus causes a significant bioterrorism threat due to the high levelof mortality, rate of transmissibility and the lack of an approved vaccine or therapy directed against it. The goal of this proposal is to develop,optimize and scale-up a mammalian cell culture-based bioprocess for the rapid manufacture of an antibody-base ...

    SBIR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  8. Plasma-Enhancement of Absorbers for Improved Removal of PFOS and PFOA from Water

    SBC: AA Plasma LLC            Topic: 17NCER1A

    New regulations and advisory levels for perfluoroalkyl substances have resulted in increased drinking water treatment costs or abandonment of drinking water sources. Treatment technologies are needed that can achieve low parts-per-trillion levels. Presently, there are insufficient treatment technologies that can destructively remove perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonic aci ...

    SBIR Phase I 2018 Environmental Protection Agency
  9. An Enhanced Contact Plasma Reactor: A Competitive Remediation Technology for Per- and Perfluoroalkyl Substance (PFAS) Contaminated Water

    SBC: Dmax Plasma LLC            Topic: 17NCER1A

    Perfluoroalkyl substances (PFASs) have received considerable attention due to their toxicity, ubiquitous presence and recalcitrance. Manufacture and disposal of PFAS-containing products has resulted in PFAS contamination of numerous water supplies. Recent reports indicate the Air Force alone is expecting to spend > $2.25 billion for cleanup for PFAS-contaminated sites. Thus, there is a huge market ...

    SBIR Phase I 2018 Environmental Protection Agency
  10. Capacitive removal of PFOA and PFOS from Drinking Water

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: 17NCER1A

    Polyfluoroalkyl and perfluoroalkyl compounds (PFCs) have been used commercially since the 1940’s due to their high level of chemical stability, almost frictionless surface or waterproofing characteristics. Elevated levels of PFCs have been linked to cancer and other health problems including reproductive and developmental risks. PFOA and PFOS are amongst the most prevalent of the PFCs with low l ...

    SBIR Phase I 2018 Environmental Protection Agency

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