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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Feasibility study of a nanostructural system for bone regeneration in preparation for dental implants

    SBC: NuShores Biosciences LLC            Topic: 100

    Project SummaryCurrent bone grafting techniques for functional rehabilitation with dental implants have limitationshighcostdifficulties with fixation and stabilizationinsufficient bone regenerationhigh morbidity using autogenous block grafts and prolonged healing of up tomonthsExisting synthetic bone fillers cannot match defect shape and volumeare weakly resorbedif at allare not easily and quickly ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of biomarkers for improved classification of membranous lupus nephritis

    SBC: NEPHROPATHOLOGY ASSOCIATES, PLC            Topic: NIMHD

    SUMMARY ABSTRACT African Americans are disproportionately affected by chronic and end stage kidney diseasewhileof patients on dialysis are African Americanonlyof the U Spopulation is African AmericanOne factor contributing to this disparity is the high incidence of autoimmune diseaseespecially systemic lupus erythematosusSLEpresent in the African American populationLupus nephritis is a common comp ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Lectin-mediated ERT Delivered to Cardiac Tissue in Fabry Disease

    SBC: Biostratagies, LC            Topic: NHLBI

    The current inability to effectively deliver corrective doses of lysosomal enzymes to key cells involved in cardiovascular and cerebrovascular disease remains a significant hurdle for rare lysosomal disordersLSDsuch as Fabry disease and other diseases with significant cardiovascular pathologiesBioStrategies LC is developing the plant lectin RTB as a carrier capable of expanding enzyme delivery toh ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Noninvasive Home Assessment of Cardiac Filling Pressure to Identify Heart Failure Patients at High Risk for Readmission

    SBC: Vixiar Medical, Inc            Topic: NHLBI

    Congestive heart failureCHFis the most common reason for hospitalization in the U Swith overmillion admissions per yearPatients admitted with CHF usually need IV diuretics to promote fluid removalThe readmission rate is highoverbydaysandbydays post dischargeThis also presents an enormous economic burdenhospitalizations account for a large percentage of the $billion spent yearly on heart failureOne ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Plug-and-Play Microsystem Enabling Highly Sensitive Analysis of Volatile Organic Compounds

    SBC: ZEBRA ANALYTIX, INC.            Topic: NIEHS

    Project SummaryThis SBIR Phase I project will investigate the technical feasibility of a microfabricated chip system for enabling on site or in fieldhighly sensitive analysis of volatile organic compoundsVOCsin aqueous samplesThe system consists of two chips in a tandem configurationThe first chip is designed to extract VOCs directly from water samplesThe extracted VOCs are concentrated in the sec ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Optimizing Direct Delivery of Nucleic Acid Therapeutics

    SBC: FHC, INC.            Topic: NIMH

    Project Summary While nucleic acid therapeutics have shown promise in rodent and nonhuman primate models of CNS diseasesall double blind clinical trials to date have failedOne likely explanation for this failure is poor therapeutic distribution in targeted brain regionsFor examplepost mortem studies of patients with Parkinsonandapos s Disease receiving intraparenchymal injections of AAV NTN demons ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Formulation and testing of an entirely wood-based exterior insulation board for the high-performance building market

    SBC: GO Lab Inc.            Topic: 17NCER6B

    The goal of this project is the formulation a rigid, insulating, low-density wood composite, with physical and thermal properties comparable to fossil fuel derived foams. _x000D_ _x000D_ To achieve energy conservation standards mandated by certification agencies such as Passive House and LEED, high performance buildings require multiple shells of insulation – an inner shell that contains electri ...

    SBIR Phase I 2018 Environmental Protection Agency
  8. RAE (Realize, Analyze, Engage)- A Digital Biomarker Based Detection and Intervention System for Stress and Craving During Recovery from Substance Abuse Disorders

    SBC: CONTINUEYOU, LLC            Topic: NIDA

    PROJECT SUMMARY The research project outlined in this SBIR submission will develop the RealizeAnalyzeEngageRAEplatform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorderIn this proposalthe investigators intend to deploy the RAE systemconsisting of a wearable sensora smartphone appand a clinical portalto provide individuals in recovery and their ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Low-Profile Dual Hormone Patch Pump with Novel Occlusion Sensor

    SBC: Sfc Fluidics, Inc.            Topic: 200

    Development of a Low Profile Dual Hormone Patch Pumpwith Novel Occlusion Sensor Project SummaryThe Specific Aim of this project is to develop a discretelow profiledual hormone drug delivery system using SFC Fluidicsenabling microfluidic technologiesA DualPumpwill be developed in which one proprietary ePumpbody will independently and accurately deliver both insulin and glucagon from two separate re ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. The Association of Late-Life Depression, Cognitive Functioning, and Sleep Disorder in Aging

    SBC: Activas Diagnostics, LLC            Topic: NIA

    Abstract There is an urgent need for new diagnostic approaches for early identification and progression in Alzheimer s diseaseADand related dementiasADRDNIA s Strategic Direction C and D to improve our understanding and develop interventions for mild cognitive impairmentMCIthe prodrome of ADThis proposal focuses on sleep statusa known hallmark of neurological diseaseand commonly present in MCI ADS ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health

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