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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Discovery of new small molecule TLR4 agonists for the treatment of allergic rhinitis

    SBC: DiaCarta            Topic: NIAID

    This pilot study is aimed at judging the efficacy of the lead compound with a clinically relevant allergenThe relevant allergen chosen for this study is the house dust mite Dermatophagoides pteronyssinus allergenDer pLoToxTM Natural Der pfrom Indoor Biotechnologies with a low endotoxin contentEUgWe are selecting this allergen because our team has extensive prior experience with this allergen in mo ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Acoustic Scaffold Bioreactor

    SBC: RESODYN CORPORATION            Topic: NHLBI

    This Small Business Innovation Research Phase II project will develop a commercially viable device that uses micro scale acoustic streaminglow frequency sound energyto deliver mixing to the interior of three dimensionalDscaffolds used for stem cell cultivation applicationsThe enabling advantage of low frequency sound energy is the ability to generate micro scale mixing in and around scaffolds that ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Noninvasive Home Assessment of Cardiac Filling Pressure to Identify Heart Failure Patients at High Risk for Readmission

    SBC: Vixiar Medical, Inc            Topic: NHLBI

    Congestive heart failureCHFis the most common reason for hospitalization in the U Swith overmillion admissions per yearPatients admitted with CHF usually need IV diuretics to promote fluid removalThe readmission rate is highoverbydaysandbydays post dischargeThis also presents an enormous economic burdenhospitalizations account for a large percentage of the $billion spent yearly on heart failureOne ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. RAE (Realize, Analyze, Engage)- A Digital Biomarker Based Detection and Intervention System for Stress and Craving During Recovery from Substance Abuse Disorders

    SBC: CONTINUEYOU, LLC            Topic: NIDA

    PROJECT SUMMARY The research project outlined in this SBIR submission will develop the RealizeAnalyzeEngageRAEplatform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorderIn this proposalthe investigators intend to deploy the RAE systemconsisting of a wearable sensora smartphone appand a clinical portalto provide individuals in recovery and their ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Discovery of NaV1.7 Inhibitors for the Treatment of Pain

    SBC: Siteone Therapeutics, Inc.            Topic: 105

    PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic painsuch as pain associated with chemotherapy induced peripheral neuropathythat targets an isoform of the voltage gated sodium ion channelNaVVoltage gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in the periphe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Plug-and-Play Microsystem Enabling Highly Sensitive Analysis of Volatile Organic Compounds

    SBC: ZEBRA ANALYTIX, INC.            Topic: NIEHS

    Project SummaryThis SBIR Phase I project will investigate the technical feasibility of a microfabricated chip system for enabling on site or in fieldhighly sensitive analysis of volatile organic compoundsVOCsin aqueous samplesThe system consists of two chips in a tandem configurationThe first chip is designed to extract VOCs directly from water samplesThe extracted VOCs are concentrated in the sec ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Adherence Monitor for Substance Use Disorder Treatment

    SBC: YELLOWSTONE SCIENTIFIC INSTRUMENTS            Topic: NIDA

    Project Summary The aim of the present SBIR program is to develop a new noninvasivepoint of care testing device for patients undergoing treatment for substance use disorderThe new device will be capable of monitoring the progress and verifying patient adherence to prescribed treatment by detecting the presence and level of a compounded adherence marker released in the urineproviding for the first ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Novel antibacterial agents derived from natural products

    SBC: Promiliad Biopharma Incorporated            Topic: NIAID

    SPECIFIC AIMSAntibiotic resistance among common bacterial pathogens is a serious public health problem as it compromises our ability to treat infectious diseaseThe resistance problem is compounded by the relative lack of discovery of new antibioticsespecially those with novel mechanisms of actionNew antibiotics are critically needed as resistance to recently developed antibiotics is growingThe goa ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Novel synthetic TLR4 agonists

    SBC: INIMMUNE CORP            Topic: NIAID

    Project SummaryThere are currently no approved vaccines for most emerging biological pathogensEbolaChikungunyaMERS CoVSARSZikaopportunistic infectionsSaureusCandidiasisadenovirusor potential bioterrorism agentsYpestisBPseudomalleiFtularensisBunyaviridaeFlaviviridaeand therapeutic interventions such as antibiotics and antivirals are only effective for a select few pathogensA promising approach for ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Acoustic Enhanced Cell Culture

    SBC: RESODYN CORPORATION            Topic: 400

    This Small Business Innovation Research Phase I project will develop a prototype and then evaluate a novel device that utilizes low frequency sound energy to enhance cell culture productivityThe acoustic micromixing generated by the proposed device is compatible with cells and possesses the capability to substantially enhance the culture efficiency of cells cultured in typical culture vesselsThis ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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