Award Data

Based on encouraging Phase I feasibility results, we propose developing a novel gene therapy approach to promote guided vascular regeneration in treating extremities after traumatic injury. Our approach is to provide thread-like implants comprised of aligned nanofibrillar collagen scaffolds loaded with Hepatocyte Growth Factor (HGF) vectors (e.g., HGF DNA plasmid, modified mRNA) designed to enhanc ...

Based on our success in developing the world first commercial high energy femtosecond fiber laser system and our leading proprietary technology development in ultrashort pulsed fiber laser material processing, PolarOnyx proposes, for the first time, a compact high energy fiber laser based smart wound healing tool to meet with the requirement of this DHP solicitation. It includes a high energy fs f ...

Biomass heating/cooking stoves in developing countries do not efficiently cook food or heat houses, while consuming too much fuel and emitting pollution resulting in respiratory illnesses, premature death, and climate change. Affordable technologies found in 1.) EPA approved heating stoves, 2.) DOE funded cooking stoves, and 3.) TEG (thermoelectric generation) lighting devices, improve heating, co ...

Over 50 million Indian households cook on a bio-mass fire and have unreliable or no electricity but are anxious to purchase an affordable power stove which will provide on-demand power and lighting to their homes. Annually, projected sales of the power stove could save sixteen million trees, reduce cooking fire particulates by 90%, reduce the two million premature deaths caused from indoor air pol ...

Discharge of nutrients (e.g. phosphorus and ammonia) to surface waters can cause eutrophication and the formation of toxic algal blooms, threatening human health and the environment. However, current phosphorus treatment technologies such as chemical precipitation and conventional biological systems can be costly and ineffective to reliably achieve impending effluent regulatory limits of

Industrial Microbes is developing a green fermentation platform to replace carbon-emitting petrochemical production with newer methods that build chemicals out of methane and carbon dioxide.Chemical production is a major source of carbon pollution, responsible for 18% of direct industrialemissions. Our innovation is an engineered microbe that can consume carbon dioxide and methane and produce a ch ...

Existing visual screening devices consist of illuminated test cards. By rotating the knob, images may be changed; however, once the system is loaded with cards it cannot be easily reconfigured. There are a limited number of cards that a unit can hold at one time, and it is impossible to change cards on the fly if a patients vision needs further investigation or if the clinician wants to do variabl ...

Despite recent tremendous leaps in the development of new technologies for image recording, presentation, manipulation, 3D capabilities, and analysis many vision exams are still performed using paper Snellen charts, paper color charts and Amsler grids. Current procedures are time consuming, labor intensive, potentially subject to transcription errors, and to test preparation or coaching, which may ...

To address the Defense Health Programs (DHPs) need for a rapid, point-of-care, comprehensive blood analysis device for diagnosis of Iron Deficiency (ID) and Iron Deficiency Anemia (IDA) in a training setting, Physical Optics Corporation (POC) proposes to develop a new Paper-based Integrated Microfluidic Hematology Analyzer (HemoPAD) for rapid point-of-care diagnosis of iron deficiency. HemoPAD is ...

DoD requires a single multiplexed salivary diagnostic bioassay to indicate early multiorgan injury to determine systemic toxicity. This assay should detect clinically validated biomarkers quantitatively in saliva to indicate organ injury due to chemical/xenobiotic exposure. Innosense LLC (ISL) will innovate on its proprietary polymer nanowire platform to fabricate Nano-Mos, which will detect saliv ...