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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Nezavist a Novel Molecule for Treatment of Alcohol Use Disorder

    SBC: LOHOCLA RESEARCH CORPORATION            Topic: 150

    Abstract for Supplement ApplicationThe ultimate goal for our original project was to complete the proof-of-concept work, and the multitude of pharmacodynamic, pharmacokinetic, toxicokinetic, safety, and toxicology studies required by the FDA to apply for an IND. We are fully satisfied that we have generated a new chemical entity that acts at a novel binding site on the GABA-A receptor and acts in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Real-time volumetric specimen imager for 3D intra-operative lumpectomy margin assessment

    SBC: CLARIX IMAGING CORP            Topic: 102

    Abstract Clarix Imaging, Corporation (Clarix) is focused on solving one of the largest problems in early stage breast cancer treatment, reoperations for positive margins. About 25% of the rt200,000 patients who undergo lumpectomy in the US each year will face this additional procedure because current options for identifying positive margins intraoperatively are insufficient. Currently physicians r ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Integrating a suite of mental health apps for depression in a healthcare setting.

    SBC: Adaptive Health, Inc.            Topic: 104

    Abstract Depression is common, imposing a tremendous societal burden in terms of cost, morbidity, quality of life, and mortality. The great majority of people with depression are treated in primary care, however outcomes remain poor. There have been two broad attempts to address this problem. One is collaborative care, which uses care managers to coordinate patient care. Collaborative care can be ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Utility of Esophageal Cooling Therapy for the Prevention of Thermal Injury During Atrial Fibrillation

    SBC: ADVANCED COOLING THERAPY INC            Topic: NHLBI

    ABSTRACT Atrial fibrillation (AF) is the most common type of heart arrhythmia; an estimated 2.7 to 6.1 million people in the United States have been diagnosed with AF and this number is expected to increase. Cardiac catheter ablation is an effective AF treatment and is performed up to a quarter million times per year in the US; however, safety concerns exist. Endoscopically detected esophageal les ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  5. A New and Disruptive Gene Based Therapy for Atrial Fibrillation

    SBC: Inomagen Therapeutics, Inc            Topic: NHLBI

    PROJECT SUMMARY Atrial fibrillation (AF) is the most common heart rhythm disorder that affects rt3 million Americans and is a major cause of stroke. Since AF is primarily an age-related disease, it is fast becoming an epidemic in a rapidly aging population. Unfortunately, current therapeutic approaches to AF – both pharmacological and ablation- based - are sub-optimal in patients with persistent ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Metastatic bone cancer and multiple myeloma affects over 600,000 people every year in the United States and cause progressive bone destruction that results in severe pain, fractures, and the inability to walk. Patients usually present with incapacitating pain secondary to osseous involvement, with or without vertebral collapse, and to spinal cord and/or nerve r ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Diversity supplement for noninvasive, wireless thermal sensors for the quantitative monitoring of ventricular shunt function in patients with hydrocephalus

    SBC: RHAEOS, INC            Topic: 102

    ABSTRACTHydrocephalus is a neurological disorder caused by buildup of excess cerebrospinal fluid (CSF) in the brain, and leads to lethargy, seizures, coma, or death. It is treated with the surgical implantation of a catheter, known as a ventricular shunt, that diverts excess CSF away from the brain and into a distal absorptive site, such as the abdomen. Unfortunately, due to occlusion or mispositi ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Commercialization Readiness for Bone Filler Scaffold Device to Aid in Dental Applications and Reconstruction

    SBC: NuShores Biosciences LLC            Topic: NIDCR

    Project Summary Current bone grafting techniques for functional rehabilitation with dental implants have limitations – high-cost, difficulties with fixation and stabilization, insufficient bone regeneration, high morbidity using autogenous block grafts and prolonged healing of up to 9 months. Existing synthetic bone fillers cannot match defect shape and volume, are weakly resorbed if at all, are ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Precisely Shaped Acoustic Ablation of Tumors Under 3D Ultrasound Image Guidance

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Many recent studies have demonstrated the efficacy of interstitial ablative approaches for the treatment of hepatic tumors, including chemical ablation, cryoablation, and thermal ablation using energy sources like RF, laser, microwave, or focused ultrasound. Despite these promising results, current systems remain highly dependent on operator skill, and cannot t ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced wireless optogenetics and photometry system for neuroscience research

    SBC: Neurolux, Inc.            Topic: 101

    Project Summary/Abstract Neuroscience research over the last decade has been revolutionized by many technological advancements. Optogenetics and fluorescence imaging represent two distinct, and sometimes complementary tools used in neuroscience research to study the central and peripheral nervous systems in the context of the BRAIN initiative. Advanced interrogations of underlying neural circuits ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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