Award Data

Abstract In response to NOT-AA-20-011, this administrative supplement will enhance the Screening, Brief Intervention and Referral to Treatment (SBIRT) support solution proposed in the parent grant (1R43AA028453-01) to help combat the dangerous combination of risky alcohol use behaviors and COVID-19, and to address the new challenges to SBIRT implementation in primary care during the COVID-19 era. ...

DESCRIPTION (provided by applicant): A binary probe-based DNAzyme cascade for rapid detection of MRSA/MSSA Project Summary This STTR Phase I project will develop a proof-of-concept molecular test for rapid detection of Staphylococcus aureus (SA) and differentiation between methicillin-resistant SA (MRSA) and methicillin-susceptible SA (MSSA) in the absence of PCR amplification. Binary DNAzyme pro ...

DESCRIPTION (provided by applicant): Ohmx Corporation is developing integrated point-of-care (POC) bioelectronic sensor technologies for protein biomarkers relevant to cancer diagnosis and risk stratification. The principal goal of this SBIR proposal is to develop an assay for prostate-specific antigen (PSA) proteolytic enzyme activity to improve the early diagnosis and prognosis of prostate cance ...

DESCRIPTION (provided by applicant): ROS Technologies, Inc, is a medical diagnostics company developing a blood test to predict sudden death risk in patients with heart failure (HF). Heart failure affects more than five million Americans and increases therisk of sudden death. This application sets out to develop a simple, inexpensive blood test to help predict sudden death risk that may prevent un ...

ABOUT 7 MILLION COUPLES IN AMERICA HAVE FERTILITY PROBLEMS, 40 TO 50 PERCENT OF WHICH ARE ATTRIBUTABLE TO THE MALE. CURRENT METHODS OF DIAGNOSING MALE INFERTILITY BY MICRO- SCOPIC EXAMINATION OF THE SEMEN SPECIMEN ARE INADEQUATE, AND MORE RELIABLE TESTS NEED TO BE DEVELOPED. THE AIM OF THIS STUDY IS TO DEVELOP SUCH A TEST BY USING A SILICA WOOL FILTRATION TECHNIQUE. THE METHOD IS BASED ON THE OBSE ...

DESCRIPTION (provided by applicant): Abstract ISS Inc. proposes to develop a novel non invasive instrument for quantitative monitoring of infant brain development. The instrument will be based on Frequency Domain Near-Infrared Spectroscopy technique and will feature eight (8) laser sources modulated simultaneously using the OFDM technology. The laser sources will emit at different wavelength. The ...

DESCRIPTION (provided by applicant): Our goals in Phases I and II have been completed and showed the feasibility of our approach for assessing brain vascular autoregulatory responses to hypoxic stimuli. Frequency Domain Near-Infrared Spectroscopy offers the advantage of performing safe, non-invasive, transcranial, quantitative, real time measurements of cerebral hemodynamics and oxygenation. Our ...

DESCRIPTION (provided by applicant): Our goals in Phase I have been completed and showed the feasibility of our approach. We applied Near-Infrared Spectroscopy (NIRS), a non-invasive method and an affordable, portable, bedside technique for the diagnosis of the degree of the hypoxic insult in the brain, in sleep apnea, during daytime napping. It has been suggested that chronic, recurrent hypoxi ...

DESCRIPTION (provided by applicant): Our ultimate project goal is to develop a patient-reported outcomes (PRO) management system specifically designed to address the functional limitations experienced by people with physical and neurocognitive disabilities. We recognize that there are many clinical conditions that could cause these functional impairments, but intend to demonstrate the technical fe ...

Not Available Nanofibers have found a market in filter applications because of their high surface area and ability to effect a large pressure drop over a small thickness. Although their use in filter applications is known, methods to produce large quantities of nanofiber sheets are kept as trade secrets, limiting the progression of this technology into other application areas of interest to the A ...