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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. TOPIC 363: myCare2- Supporting Caregivers and Caregiving

    SBC: BRIGHTOUTCOME INC.            Topic: NCI

    The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Nonsense Suppressing Drugs for Rett Syndrome

    SBC: Starwise Therapeutics LLC            Topic: 103

    Nonsense Suppressing Drugs for Rett Syndrome Rett syndromeRTTis a devastating genetic condition that affects mostly femalesIt is one of the worst types of neurodevelopmental disordersthe affected girls are born without any obvious problemsdevelop in a seemingly typical manner for the first year of lifebut then abruptly and without warning lose most of their acquired abilitiesRTT girls then typical ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Integrated System for Rapid Production of Activated Sugars and Glycosylated Molecules

    SBC: ZUCHEM INC.            Topic: 300

    Glycan modifications of natural products are increasingly important in the discovery of new pharmaceuticalsWhile glycodiversity gives rise to important therapeutic properties of bioactive moleculesexploring glycodiversity has challengesIsolating glycosylated compounds from nature is often difficult due to low concentrations and the presence of multiple related molecules with similar structures and ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Middle-ear reflex testing using WAI

    SBC: Mimosa Acoustics Inc.            Topic: NIDCD

    PROJECT SUMMARYThe purpose of the proposed project is to combine wideband acoustic immittanceWAIand middle ear muscle reflexMEMRtesting using new approaches that improve sensitivityincrease test efficiencyand provide objectivity in interpretationAcoustically elicited MEMRs have a long history of value in the clinical evaluation of hearing lossWhile sensitive to and affected by middle ear disorders ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Clinical optical coherence tomography for retinal metabolic imaging

    SBC: OPTICENT, INC.            Topic: NEI

    PROJECT SUMMARY Diabetic retinopathyDRis a complication of diabetes and a leading cause of blindness in the worldAlthough it is widely accepted that DR is driven by ischemiathe current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non proliferative DR or angiogenesis in proliferative DRAs a resultmost patients have alrea ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. A Sensor-based Platform for Hand Hygiene Tracking and Analysis

    SBC: Microsensor Labs, LLC            Topic: 600

    Project Summary This Small Business Innovation Research Phaseproject aims to develop and characterize a sensor based platform to track and analyze healthcare providershand hygiene quality and compliance automatically and continuouslyHealthcare Associated InfectionsHAIsare the most common type of complication for patients who are hospitalizedIn the United Statesout of everyhospitalized patients is ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. MPS I Skeletal Disease Therapy with Novel Lectin-delivered Replacement Enzyme

    SBC: Biostratagies, LC            Topic: NIAMS

    BioStrategies LC is developing the plant galactose binding lectinRTBas an enzyme carrier capable of expanding delivery of enzyme replacement therapiesERTstohardto treatorgans and tissues such as boneThe rare lysosomal disease mucopolysaccharidosis IMPS Iis a progressive multisystem disorderwhich presents with significant skeletal abnormalities that play a major role in patient disease progressionM ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. The first cell-based and label-free, high-throughput assay of specific enzyme activities

    SBC: SAMDI TECH, INC.            Topic: 950

    Project SummaryAbstract Cell based assays that investigate the effect of small molecules on cellular activities are becoming increasingly popular screening tools for drug discoveryThe ability to assess small molecules in a physiologically relevant environment is informativeas the assays simultaneously evaluate compound permeabilitytoxicityand activityYetcell based assays are often limited to detec ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Wireless Movement Sensing System for People with Severe Disabilities

    SBC: INVOTEK, INC.            Topic: NIDCD

    Abstract The ability of people with severe physical impairment to participate in family lifecommunicationworkor recreation is severely restricted without access to assistive technologyATYetas disability severity increasesso does the challenge to findingan access movement that a person can perform to control AT andan access technology that can detect the access movementWe propose to create a wirele ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A novel glutaminase-free mammalian asparaginase with minimized immunogenicity to enable expanded use in cancer therapy

    SBC: Enzyme by Design Inc.            Topic: 102

    Project SummaryThe goal of this proposal is to develop a significantly safer variant of the anti cancer biologic drug LasparaginaseASNaseASNases are enzyme drugs that systematically deplete L asparagine from the bloodFirst generation ASNases are approved by the FDA for the treatment of acute lymphoblastic leukemiaALLa cancer of white blood cellsThis generationincluding enzymes from EcoliElsparand ...

    STTR Phase I 2018 Department of Health and Human Services

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