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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

Displaying 1 - 10 of 4330 results
  1. Reducing Methadone's Arrhythmic potential

    SBC: Academic Pharmaceuticals Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): Methadone is an important long-term maintenance therapy for drug addiction and currently is frequently used for analgesia. However, methadone prolongs the QT interval on the electrocardiogram and this increases risk for life threatening arrhythmias and has led to the FDA's placing a black box warning on methadone's label. Initial studies in our laboratory hav ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  2. Development of an anti-bias caster system

    SBC: ACCESSIBLE DESIGNS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The importance of reducing the incidence of secondary injuries related to manual wheelchair propulsion is undisputed. Based on several research studies, approximately 50% of manual wheelchair users (MWU) report symptoms of repetitive strain injury (RSI) related to the demand on the upper extremity during propulsion and transferring tasks. A substantial effort ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Demand Driven Healthcare Scheduling using Flexible Shifts and Monte-Carlo Simulat

    SBC: Acme Express, Inc.            Topic: NINR

    DESCRIPTION (provided by applicant): The shortage of nurses and medical technologists is accelerating. Shortages can be reduced by scheduling staff to precisely meet the hour-by-hour demand for medical service. Think of bank teller scheduling, where more staff are scheduled at peak demand. Current attempts to schedule to demand are relatively primitive: a small number of quantized fixed shifts, fo ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  4. Refinement of lead compounds to modulate water permeability through AQP4

    SBC: AEROMICS, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Cerebral edema (and its counterpart in the spinal cord) is a major contributor to the damage caused by stroke, traumatic brain injury, traumatic spinal-cord injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leading cause of disability. Unfortunately, few treatment options are available for cerebral and spinal- ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  5. New Reagents for Synthesis of High Potency siRNA

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): New Reagents for Synthesis of High Potency siRNAs Abstract Since the discovery of short interfering RNA (siRNA) molecules in the late 1990s, siRNA technology has developed rapidly as a powerful tool for functional genomic analysis, target validation and therapeutic purposes. However, the potency and persistence of unmodified siRNAs is dramatically limited by th ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  6. THIOAPTAMER CAPTURE FOR ADDICTION-RELEVANT PROTEINS

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIDA

    AM Biotechnologies (AM) will develop renewable thioaptamer protein capture reagents to ten proteins related to drug addiction. Thioaptamers are a type of aptamer containing phosphorodithioate linkages and other modifications that have excellent affinity and specificity for proteins. Because of the unique chemical composition of thioaptamers, they cannot be developed using the Systematic Evolution ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Identification of microRNA Biomarkers for Colon Cancer Recurrence Risk Stratifica

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The current primary form of treatment for all stages of colon cancer is surgical resection, with overall survival rates depending upon whether the cancer recurs and metastasizes. The likelihood of recurrence is directly related to the stage of cancer, which is determined by the depth of tumor penetration into the wall of the colon. Recurrence rates range from 2 ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. Technologies for mapping interspersed AGG sequences in the FMR1 gene

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The objective of this project is to develop a comprehensive set of assays to improve screening and prediction of conditions associated with fragile X syndrome (FXS). FXS, which affects approximately 1/4000 men and 1/6000 women, is caused by an expansion of a cytosine-guanine-guanine (CGG) triplet repeat in the 52 untranslated region (UTR) of the FMR1 gene. The ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. Amplification Strategies for Detection of Fragile X Gene Trinucleotide Repeats

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall objective for this project is to develop and implement a comprehensive set of technologies to improve screening and diagnosis of conditions associated with Fragile X Syndrome (FXS). FXS is caused by an expansion of a cytosine-guanine-guanine (CGG) triplet repeat in the 5'-untranslated region of the FMR1 gene. FXS affects 1/4000 men and 1/6000 wo ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  10. Nano-Enhanced Composite Electrodes for Electrostatic Precipitators

    SBC: Applied Sciences Inc.            Topic: TopicF

    With the increasing volatility of petroleum and natural gas resources, small coal-fired boilers have become increasingly more attractive for steam and power generation in several industries. This switch to small-scale, coal-fired plants is expected to continue, and increases the need for clean coal utilization technology. The U.S. Energy Policy Act includes support for a clean coal technology init ...

    SBIR Phase II 2010 Environmental Protection Agency
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