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THE LONG-RANGE GOAL OF THIS PROGRAM IS THE DEVELOPMENT AND COMMERCIALIZATION OF A PROTON THERAPY DELIVERY SYSTEM THAT WILL LEAD TO A SUBSTANTIAL ADVANCEMENT OVER EXISTING METHODSOF CANCER TREATMENT WITH PROTONS. DELIVERY SYSTEM COMPONENTS WILL INCLUDE RASTER SCANNING MAGNETS, SMALL APERTURE BENDING MAGNETS, GANTRY SYSTEMS, AND PERMANENT MAGNET TRANSPORT SYSTEMS OF WIDE MOMENTUM ACCEPTANCE. SUCH EQ ...

THIS PROJECT WILL DEVELOP AND TEST THE PROTOTYPE OF A NEW INSTRUMENT FOR MEASURING HORIZONTAL, VERTICAL, AND TORSIONAL EYE POSITIONS NONINVASIVELY, UNOBTRUSIVELY, AND SIMULTANEOUSLY. TESTING WILL BE DONE BY MEASURING A SIMULATED EYE AND BY COMPARING MEASUREMENTS ON HUMANS WITH THOSE MADE BY OTHER INSTRUMENTS. THE PROTOTYPE WILL HAVE A DIRECTIONAL RESOLUTION OF BETTER THAN 2 ARC MINUTES OVER +45 DE ...

THE ACCEPTANCE OF EXTRACORPOREAL OXYGENATION DEVICES BASED ON GAS TRANSFER THROUGH A MEMBRANE WILL DEPEND TO A LARGE EXTENT ON THE AVAILABILITY OF SIMPLER, EASIER TO USE, SAFER,AND LOWERCOST DEVICES. OXYGENATORS USING MICROPOROUS HOLLOWFIBERS HAVE COME INTO WIDER USE THE LAST FIVE YEARS. THEY PRESENT MORE MEMBRANE SURFACE TO BLOOD AND GAS PHASES FOR EQUIVALENT VOLUME AND DO NOT REQUIRE A SUPPLEMEN ...

CLASSICAL ASSAYS FOR DETERMINING BLOOD AND URINE GLUCOSE HAVE LIMITED VALUE FOR THE MONITORING OF AN INDIVIDUAL'S BLOOD GLUCOSE LEVEL OVER TIME. MEASUREMENT OF GLYCATED HEMOGLOBIN (GHB) IS ALREADY GAINING ACCEPTANCE FOR MANAGEMENT OF PERSONS WITH DIABETES MELLITUS. GHB LEVELS ARE NOT ONLY USEFUL FOR DIAGNOSIS BUT ALSO FOR THE ESTABLISHMENT OF CARE GOALS AND FOR CARE REINFORCEMENT. IN THE FUTURE, M ...

THE TRAVEL TIMES OF COHERENT EVENTS IN SEISMIC SURVEYS OF THE CRUST PRINCIPALLY GIVE INFORMATION ABOUT THE LOW SPATIALFREQUENCY VELOCITY FIELD; DETAILS OF THE SEISMIC SIGNATURES OF BACKSCATTERED EVENTS PRINCIPALLY GIVE INFORMATION ABOUT THE HIGH SPATIAL FREQUENCY OF THE VELOCITY AND DENSITY FIELDS (WHICH CAN BE REPRESENTED BY PSEUDO WELL LOGS). TRAVEL TIME INVERSION IS BEGINNING TO FIND PRACTICAL ...

THIS PROGRAM IS RELATED TO THE DEVELOPMENT OF A PLATINUM-POLYSTYRENE ELECTRODE WITH TEXTURED SURFACE FOR A SUBCUTANEOUS ELECTROCATALYTIC SENSOR. THE SUBCUTANEOUS SENSOR HAS LOWER RISKS COMPARED TO AN INTRAVENOUS SENSOR, SOIT IS CONSIDERED FOR LONG-TERM MONITORING PURPOSES. IT HAS BEEN DEMONSTRATED THAT TEXTURED SURFACES ARE FAVORABLE FOR IMPLANTATION TO THE SOFT TISSUE DUE TO BETTER VASCULARIZATIO ...

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PLASTIC SCINTILLATING OPTICAL FIBERS (PSF) WILL PLAY A MAJORROLE AS RADIATION DETECTORS IN THE GIANT RESEARCH DEVICES ENVISIONED FOR THE SUPERCONDUCTING SUPER COLLIDER (SSC) AND FOR OTHER SIMILAR DEVICES PLANNED ABROAD. THIS PROJECT IS CONCERNED WITH ESTABLISHING A DOMESTIC COMMERCIAL SOURCE OF THIS NEW GENERATION DETECTION MEDIUM NEEDED FOR THE ADVANCEDPARTICLE PHYSICS RESEARCH TO BE CONDUCTED AT ...

TWO TYPES OF INSTRUMENT ARE EMERGING FOR THE AUTOMATED MEASUREMENT OF DNA. ONE USES FLUORESCENT LABELING AND DETECTION IN THE GEL. THE OTHER USES RADIOACTIVE LABELING AND DETECTION FROM AN AUTORADIOGRAM. INNOVATIONS SUCH AS MULTIPLEX SEQUENCING SUGGEST THAT BOTH TECHNIQUES WILL BE USED IN YEARS TO COME FOR BOTH MAPPING AND SEQUENCING. INSTRUMENTATION FOR THE TWO APPROACHES HAS BEEN SOPHISTICATED A ...