Award Data

DESCRIPTION (provided by applicant): Digoxin is the first line pharmacologic therapy for CHF and AF. Digoxin increases cardiac contractility and blocks conduction through the AV node slowing the ventricular response to AF and thus slowing the rate of the beating ventricles permitting more time for the heart to fill. The recent Dig trial supports the use of digoxin in the treatment of CHF and the r ...

THE LONG-RANGE GOAL OF THIS PROGRAM IS THE DEVELOPMENT AND COMMERCIALIZATION OF A PROTON THERAPY DELIVERY SYSTEM THAT WILL LEAD TO A SUBSTANTIAL ADVANCEMENT OVER EXISTING METHODSOF CANCER TREATMENT WITH PROTONS. DELIVERY SYSTEM COMPONENTS WILL INCLUDE RASTER SCANNING MAGNETS, SMALL APERTURE BENDING MAGNETS, GANTRY SYSTEMS, AND PERMANENT MAGNET TRANSPORT SYSTEMS OF WIDE MOMENTUM ACCEPTANCE. SUCH EQ ...

DESCRIPTION (provided by applicant): Flow cytometers are valuable tools for the rapid analysis of cells and macromolecules for both research and diagnostic purposes. Ideally, flow cytometry based analysis could benefit more researchers and clinicians if the units were more affordable, smaller, and even portable. New fabrication techniques and design approaches developed in the microfluidics and la ...

DESCRIPTION (provided by applicant): Broadband impedance analysis of individual cells yields a wealth of information about cell size, viability, morphology and interior structure. Cell dielectric properties including membrane conductivity, cytoplasmic conductivity, and membrane capacitance can be derived from multi-frequency impedance data and used to differentiate and enumerate cell populations i ...

Emissions of volatile organic compounds (VOCs) and hazardous air polutants (HAPS are a serioud environmental issue. These pollutants are requlated to protect human health and encourage the development of better control technologies. Current technologies to control thses emissions, until better materials are developed, include destructive and/or recovery-based technologies. Implementation of ads ...

DESCRIPTION (provided by applicant): Clinical urinalysis is performed to examine the chemical and formed particle composition of urine. It is used as a screening and/or diagnostic tool to detect different metabolic and kidney disorders, urinary tract infections, diabetes and pregnancy. Routine urinalysis consists of a physical (color, clarity, odor), chemical (protein, glucose, nitrites, etc.), an ...

THIS PROJECT WILL DEVELOP AND TEST THE PROTOTYPE OF A NEW INSTRUMENT FOR MEASURING HORIZONTAL, VERTICAL, AND TORSIONAL EYE POSITIONS NONINVASIVELY, UNOBTRUSIVELY, AND SIMULTANEOUSLY. TESTING WILL BE DONE BY MEASURING A SIMULATED EYE AND BY COMPARING MEASUREMENTS ON HUMANS WITH THOSE MADE BY OTHER INSTRUMENTS. THE PROTOTYPE WILL HAVE A DIRECTIONAL RESOLUTION OF BETTER THAN 2 ARC MINUTES OVER +45 DE ...

DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States and is the number one cause of adult disability. It is estimated that this clinical condition results in a cost of $30-40 billion in the U.S alone. While a large number of therapeutic agents have been investigated for the treatment of ischemic stroke, only one agent is currently approved for marke ...

DESCRIPTION (provided by applicant): Advaxis will develop a novel Listeria monocytogenes based vaccine against the human HER-2/neu protein that will be a safe and effective therapeutic vaccine for the treatment of HER-2/neu overexpressing breast carcinomas. Breast cancer, the most common type of cancer in women, is a complex disease with no single causative agent or event. There are several tumor- ...

DESCRIPTION (provided by applicant): The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma. Asthma is one of the most prevalent chronic inflammatory diseases in the United States affecting approximately 15 percent of the population. Despite intensive research on as ...