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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. C-arm Fluoroscopy for Prostate Brachytherapy

    SBC: BURDETTE MEDICAL SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A technique is proposed for the development of an intraoperative, 3-dimensional registration of C-arm fluoroscopic images with spatially-registered ultrasound visualization and implant guidance of radioactive implants and on-line implant assessment during the procedure for treatment of prostate cancer. With present techniques using transrectal ultrasound guidan ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  2. Design & Synthesis of Novel Agents to Treat Amyloidosis

    SBC: Advanced Life Sciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The major goal of our proposed project is to advance the development of novel compounds for the treatment of amyloidosis and other protein aggregation diseases. Preliminary work demonstrated that two chalcones inhibited amyloid fibril formation, in vitro, and that further work is warranted. The amyloid diseases that arise from nonimmunoglobulin proteins includ ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. Potential Brain Therapeutics

    SBC: AMERICAN BIOTECHNOLOGY RESEARCH CORP            Topic: N/A

    DESCRIPTION (provided by applicant): Use of botanical products such as exogenous antioxidants has gained considerable momentum in the last few years in therapy of human degenerative diseases. Among these antioxidants, tumeric, neem, guggul, alpha-tocopherol, Beta-carotene, and ascorbic acid have been shown to have a special relevance in maintaining the redox e ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  4. Optical Trapping

    SBC: Arryx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the incident light) it's ability to manipulate biological particles such as macromolecules, viruses, microtubul ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Molecular Manipulation with a Holographic Laser Tweezers

    SBC: Arryx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Manipulation of objects on a microscopic scale can be done conveniently with a device known as a laser or optical tweezers. While laser trapping was originally devised for trapping Rayleigh particles (i.e. particles much less than the wavelength of the incident light) it's ability to manipulate biological particles such as macromolecules, viruses, microtuble ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. Cartilage Repair by Engineered Implant Feasibility study

    SBC: ARTICULAR ENGINEERING, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This small business Innovation Research Phase I project proposes to define methodology to facilitate the growth of engineered cartilage tissue. Recent studies have demonstrated that the alginate recovered chondrocyte (ARC) method can be used to stimulate isolated adult articular chondrocytes in vitro to form viable cartilaginous tissue with good physiochemical ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  7. Effective Oral Iron Supplement for Pre-dialysis Patients

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Development of anemia is a major problem in chronic renal failure. Its prevention/early treatment with recombinant human erythropoietin (rHuEpo) during pre-dialysis phase is important. Available iron is required for efficient action of rHuEpo; iron supplements are often needed; oral iron therapy is the preferred mode. Availability of oral iron varies widely in ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  8. CULTURED CILIATED CELLS FOR HIGH THROUGHPUT SCREENING

    SBC: BIOTECHPLEX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): BioTechPlex proposes to develop mammalian tracheal/bronchial airway epithelial cell line, CILSCREEN TM, specifically for high throughput screening. This is based on physiological functional assays. BioTechPlex has accomplished all the proposed Phase I objectives. A) Successfully developed techniques to culture and numerically expand airway epithelial cells whil ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  9. CULTURED CILIATED CELLS FOR HIGH THROUGHPUT SCREENING

    SBC: BIOTECHPLEX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): BioTechPlex proposes to develop mammalian tracheal/bronchial airway epithelial cell line, CILSCREEN TM, specifically for high throughput screening. This is based on physiological functional assays. BioTechPlex has accomplished all the proposed Phase I objectives. A) Successfully developed techniques to culture and numerically expand airway epithelial cells whil ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  10. TRANS-MEMBRANE WATER AND ION MEASUREMENT SYSTEM (TWIMS)

    SBC: BIOTECHPLEX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): BioTechPlex proposes to develop a Transmembrane Water and Ion Measurement System (TWIMS) to measure miniscule water fluxes across biological membranes in conjunction with their electro-physiological properties. BioTechPlex has accomplished all the objectives proposed in Phase I. A) Developed a novel light source and associated optics for fluorescence photon ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
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