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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Methods for Fast and Efficient Oxygen Imaging

    SBC: O2M TECHNOLOGIES LLC            Topic: 102

    Abstract Intermittent or acute/cyclic hypoxia in tumors, with frequencies between a few cycles per minute to hours, is receiving increased attention because this type of hypoxia has been reported to have an influence on tumor malignancy as well as treatment resistance via increased expression of pro-survival pathways. Fast oxygen imaging methods are needed for the measurement of acute tumor hypoxi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Image-based risk assessment to identify women at high-risk for breast cancer

    SBC: WAVED MEDICAL LLC            Topic: NCI

    7. PROJECT SUMMARY Breast cancer is the most common cancer worldwide and the most common cancer diagnosed in American women. While there has been good progress regarding detection and treatment methods, breast cancer remains the primary cause of death from malignant tumors. Hence, there is a critical need for the development of novel predictive and prognostic factors. Risk assessments are currentl ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Seaweed-based bioplastic replacement for commercial lobster fishing gear.

    SBC: VIABLE GEAR LLC            Topic: 93

    Viable Gear will provide proof-of-concept for a seaweed-based bioplastic to be used in manufacturing a compostable biotwine for marine equipment, designed to replace petroleum-based plastics. This addresses NOM-SBIR research topic area 9.3, The Changing Ocean - specifically to "support increased protection and restoration of marine and coastal habitats to enhance vital ecosystems", by helping decr ...

    SBIR Phase I 2023 Department of CommerceNational Oceanic and Atmospheric Administration
  4. AeroLite Sense: Atmospheric Aerosols and Particulates Observations from the Stratosphere

    SBC: STRATOSOLUTIONS INC            Topic: 91

    The long endurance “StratoSonde” lighter-than-air, uncrewed system combines a low-cost, 5day endurance StratoSonde supports up to 10 micro-dropsondes, which when released from the HAB, descend safely through the entire atmospheric column under a ribbon drogue while reporting observations directly back to the HAB. This project will assess the feasibility of integrating a disposable miniature ae ...

    SBIR Phase I 2023 Department of CommerceNational Oceanic and Atmospheric Administration
  5. A point-of-care salivary cytokine test for early detection of oral cancer

    SBC: GLUCOSENTIENT INC            Topic: 100

    Project Summary / AbstractOral cancer is the 6th most common cancer globally with ~ 350,000 new cases and claiming ~ 180,000 lives annually. Common risk factors include smoking and alcohol consumption. However, other local habits, such as khat chewing, can cause significantly higher regional higher prevalence (up to 40% of all cancer cases in some Asian countries). Currently, identification and di ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. SMALL MOLECULE THERAPEUTIC FOR ALZHEIMER'S DISEASE

    SBC: SOMATOLYNK, INC.            Topic: NIA

    An estimated one out of eight individuals over the age of 65 has Alzheimer’s disease (AD), with a prevalence of 1-in-3 for those over age 85. There are approximately 5.8 million people in the USA with AD, with a global projection of over 150 million by 2050. There remains a lack of effective treatment to halt disease progression. Somatostatin receptor-4 (SSTR4) represents an innovative and viabl ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Mature brain organoid platform for therapeutic screening for ALS/FTD

    SBC: SYNAPTICURE INC            Topic: 105

    Abstract Synapticure is developing a novel patient-derived 3D platform for high-fidelity modeling and screening of TDP- 43 proteinopathy and associated biomarkers for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Synapticure’s mature brain organoids (mbOrgs) are composed of key neural cells derived from patient- induced pluripotent stem cells (iPSCs) and are custom assem ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Selective Activators of Nrf2 for Neurodegenerative Disease

    SBC: GROVE BIOPHARMA, INC.            Topic: 105

    Protein-like polymers (PLPs) are next generation biotherapeutics with the potential to improve treatment outcomes for patients suffering from devastating neurodegenerative diseases. We have developed a lead PLP that disrupts the Keap1-Nrf2 intracellular protein-protein interaction (PPI) that restricts the therapeutic activity of Nrf2 (nuclear factor-erythroid factor 2-related factor 2), a validate ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Development of A Novel Nanoparticle Biosensor for Rapid, Point-of-Care Sepsis Diagnosis and Risk Assessment

    SBC: NAMI DIAGNOSTICS LLC            Topic: NIAID

    Abstract. In the United States, about 1.7 million adults affected by sepsis annually, which leads to more than 270,000 deaths per year. If sepsis cannot be diagnosed and treated early, it not only causes high morbidity and mortality rates, but also poses a major burden to the healthcare system since septic patients are generally hospitalized for extended stay and rarely discharged from ICU before ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Extraordinary Dispersion Engineering In Enabling Ultrafast Swept Source visiblelight Optical Coherence Tomography

    SBC: OPTICENT, INC.            Topic: NEI

    Project Summary This SBIR Phase 1 project focuses on developing, characterizing, and validating a new swept-source laser system to enable the next-generation clinical visible-light optical coherence tomography (vis-OCT). We will develop a novel design of photonic bandgap fiber that comprises Fiber Bragg Grating array to temporally disperse broadband picosecond-pulses to create a wavelength sweepin ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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