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ABSTRACT Extracorporeal membrane oxygenation ECMO use continues to increase as a supportive measure for cardio respiratory failure Pediatric patients with severe acute left ventricular LV systolic dysfunction are often supported with venoarterial VA ECMO as a short term bridge to recovery transplant or a ventricular assist device VAD Although this often provides the much needed tempora ...

Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral infection and pathogenes ...

Abstract Prospective cohort studies in individuals at risk for Type diabetes T D have established that diagnosis of the disease occurs at a late stage in the progressive decline in cell function when the majority of cell function has been lost and the possibility for disease prevention is gone Current measures of autoantibodies HLA typing and oral glucose tolerance tests OGTT are abl ...

DESCRIPTIONprovided by applicantThis Phase I II Fast Track application is being re submitted under the NHLBI Small Business Topics of Special Interest for Fiscal YearHLSCertain life saving interventions such as cardiopulmonary bypassCPBextracorporeal membrane oxygenationECMOor ventricular assist deviceVADpump require the use of high dose heparin to maintain blood flow through the devices and or to ...

Traumatic brain injury TBI is an acquired neurological disorder that can cause long lasting disability with limited treatment options Therefore preventative strategies must be emphasized in high risk activities to reduce the individual and societal burden of this pervasive injury Bicycle activities account for of all sports related TBI with over annual injuries in the US In an e ...

Influenza A viruses belong to the orthomyxoviridae family with a negative sense segmented RNA genome which can cause seasonal or pandemic flu with high morbidity and significant mortality Vaccination is the most prevalent prophylactic means for controlling influenza infections However an effective vaccine usually takes at least months to develop for the circulating strains Furthermore vac ...

DESCRIPTION provided by applicant This application is in response to RFA EB a special SBIR program to reduce health disparities by developing medical technologies that are andquot effective affordable culturally acceptable and easily accessible to those who need them andquot It is based on the well established partnership between BrightOutcome and Dr Ana Maria Lopez Associate Vice ...

Clostridium difficile infectionthe cause of antibiotic associated pseudomembraneous colitisis a growing national health problemThe incidence of primary Clostridium difficile infection in the hospitalized U Spopulation is greater thancases annuallyThere is a high incidence of relapseCdifficile infection is also a significant problem among patients with ulcerative colitisThis infection is often diff ...

DESCRIPTION provided by applicant Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment again ...

ABSTRACT Detecting change in neuropsychological functioning over time is critical for proper diagnosis and management of many neurological psychiatric and psychological conditions It is well documented that most commonly used cognitive assessments produce significant retest effects such as practice and regression to the mean effects Retest effects can cause substantial changes in test score ...