Award Data

Project Summary Abstract Diseases of the central and peripheral nervous systems affect the quality of life of millions of people worldwide Progress in understanding the function of neural networks and in developing associated insights into the underlying causes of these diseases can be accelerated by advances in techniques and methodologies for neuroscience research Collaborative efforts between ...

ABSTRACT Alzheimerandapos s and other tauopathies are medical problems growing to historical proportions that threaten the long term viability of medical care systems world wide Alzheimerandapos s costs today are of the US GDP and growing as the population ages Effective disease modifying treatments have yet to be developed A number of drugs in clinical testing target amyloid but very fe ...

PROJECT SUMMARY DR is a secondary complication of diabetes and a leading cause of blindness in the world Although it is well known that DR is driven by ischemia the current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non proliferative DR and angiogenesis in proliferative DR As a result when their diagnosis is first ...

PROJECT SUMMARY There are currently over patients on peritoneal dialysis PD around the globe Clinical outcomes are dictated largely by the dextrose and sodium concentrations used in each session However the state of the art in APD systems is woefully deficient clinicians must choose from only dialysate dextrose concentrations available and have no choice for sodium concentration W ...

The World Health Organization estimates that bymajor depressive disorderMDDwill be the most common cause of disabilityworldwideAlthough approximatelyinAmericans will suffer from MDD during their lifetimemany patients with MDD go undiagnosed in primary care settingsandare incorrectly diagnosed with MDDGiven the substantial medicaleconomic and social costs involved with MDDthere is tremendous need f ...

PROJECT SUMMARY ABSTRACT The US Surgeon General reports that skin cancer is the most common type of cancer in the US The number of Americans who have had skin cancer at some point over the last three decades is estimated to exceed all other cancers combined There are more than new cases of melanoma each year resulting in more than deaths Reports indicate that nearly of skin c ...

Abstract Antibody dependent cellular cytotoxicity ADCC mediated by natural killer NK cells is a key effector function of therapeutic monoclonal antibodies mAb in use for treatment of established cancers mAbs communicate with NK cells via the low affinity Fc receptor IIIa Fc RIIIa mAbs bound to targets on cancer cells promote crosslinking of Fc RIIIa and activation of NK cells leading ...

Sepsis induced ALI ARDS is a devastating syndrome of acute respiratory failure in critically ill patients that accounts for among the highest admission rates in ICU and mortalityDuring STTR Phasewe at Cell Biologics Incdemonstrated that piceatannola naturally occurring anti inflammatory that selectively inhibits Syk tyrosine kinasewhen entrapped in innm albumin nanoparticlesPANPswas therapeuticall ...

Project Summary Methadone is a synthetic opioid used to treat pain and as maintenance therapy for opiate addicted individuals Methadone does not have the euphoric properties of morphine and thus is less addictive Its use in the treatment of both acute and chronic pain thus offers advantage However limiting methadone s clinical use is its prolongation of the cardiac cell s repolarization time ...

PROJECT SUMMARY Prenatal alcohol exposure is the leading preventable cause of birth defects in the United Statesproducing an array of neurologicalbehavioral and physical abnormalities collectively known as fetal alcohol spectrum disordersFASDEarly intervention and treatment programs have been shown to reduce some of the long term adverse effectsbut this is dependent on identifying children at risk ...