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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. New drug VS-110 for treating inflammatory bowel diseases

    SBC: Vidasym, Inc            Topic: NIDDK

    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) involve chronic inflammation of all or part of the digestive tract. Symptoms may include abdominal pain, severe diarrhea and malnutrition. IBD primarily includes ulcerative colitis (UC)and Crohn's disease (CD). In the West, the prevalence has increased in the past 50 years to 120-200/100,000 persons for UC and 50-200/100,0 ...

    STTR Phase I 2013 Department of Health and Human Services
  2. Nanocytological Fecal Assessment to Personalize Colonoscopic Surveillance

    SBC: NANOCYTOMICS LLC            Topic: NCI

    DESCRIPTION (provided by applicant): The clinical impact of the 5 million annual surveillance colonoscopies (follow up of previous neoplasia) is remarkably low (gt90% without significant neoplasia). Juxtaposed with this is the alarmingly frequent occurrence of colorectal cancers (CRCs) in between colonoscopies (interval cancers), especially in the proximal colon. The medico-legal and clinical con ...

    STTR Phase II 2013 Department of Health and Human Services
  3. Novel SET Antagonists for the Treatment of Chronic Myelogenous Leukemia

    SBC: United States Drug Testing Laboratories, Inc.            Topic: NIAAA

    PROJECT SUMMARY Prenatal alcohol exposure is the leading preventable cause of birth defects in the United States, producing an array of neurological, behavioral and physical abnormalities collectively known as fetal alcohol spectrum disorders (FASD). Earlyintervention and treatment programs have been shown to reduce some of the long-term adverse effects, but this is dependent on identifying childr ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. Clinical Development of a Stable Glucagon Formulation for Bi-hormonal Pump

    SBC: Vidasym, Inc            Topic: NIAMS

    DESCRIPTION (provided by applicant): Osteoporosis is a major public health threat. National Osteoporosis Foundation estimated that the US national direct expenditures for osteoporotic hip fractures were at 17 billion in 2005 and it would increase to 25billion in 2025. Current treatments for osteoporosis include several anti-resorptive (or anti-catabolic) and some anabolic agents. VDRMs such as ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. Diametrically Patterned Dural Graft for Enhanced Dura Mater Regeneration

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Prostate cancer affects one in every six men and remains the second leading cause of cancer related mortality in men. Permanent interstitial brachytherapy, the permanent placement of radioactive seeds in the prostate, is widely used in the treatment of prostate cancer. Despite the recent uptake in robotic surgery (with reported increased urinary morbidity) whic ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. Screens for Novel Agonists/Antagonists of Endocrine Fibroblast Growth Factors

    SBC: GlucoSentient, Inc            Topic: NIDA

    DESCRIPTION: Substance use disorder (SUD) is a major health problem with direct and indirect impact on healthcare and societal cost that is estimated at over 181 billion annually in the United States. Opioids are the second most abused substances and buprenorphine (BUP) is an effective and safe medication for opioid dependence. However, BUP remains a narcotic, and strict BUP compliance is critic ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. Small Cell-Penetrating Glyco-Decoys Sidetrack Selectin Ligand Biosynthesis

    SBC: MATERIALS DEVELOPMENT, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Advanced Image Plates for Dental X-ray Diagnostics The proposed research and development project will enhance medical imaging technology for use in dental imaging. This overall objective provides an important opportunity to enhance the technical quality and patient experience in dental care. The RandD will investigate the use of high-resolution Transparent Stor ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. Pharmacological Targeting of Endothelial Dysfunction in Atherogenesis

    SBC: DIAGNOSTIC PHOTONICS, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Diagnostic imaging in modern dental practice still relies mainly on visual inspection or x-ray radiography, a technology that remains largely unchanged since the late 1800s. The early detection of small caries and the evaluation of microscopic enamel cracks prior to facture are two major issues that may be addressed with the application of 3-D optical imaging t ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Tailored telehealth weight management tool to overweight adults with disabilities

    SBC: BRIGHTOUTCOME INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): People with disabilities experience poorer health and have much higher rates of obesity compared to the general population. For the more than 54 million individuals with disabilities in the U.S., there is a significantly higher risk of poorly managed health care. It is estimated that the total national disability-associated health care expenditures (DAHE) were ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. Development of a Urine Test for the Early Detection of Liver Cancer

    SBC: GlucoSentient, Inc            Topic: NIDDK

    DESCRIPTION (provided by applicant): While the high costs of healthcare in the U.S. can be felt by everyone in the country, the economic impact to patients with kidney failure is particularl significant as dialysis treatments can reach 85,000 annually, with transplantation being the only known cure. Therefore, kidney transplants today make up more than half of all transplants performed in the U.S ...

    SBIR Phase I 2013 Department of Health and Human Services

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