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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topically-delivered Mutation-specific Gene Targeting for Epidermolytic Ichthyosis

    SBC: Exicure, Inc.            Topic: NIAMS

    DESCRIPTION (provided by applicant): AuraSense Therapeutics (AST), along with Northwestern University, is applying a recently developed technology using oligonucleotide-functionalized nanoparticles (called spherical nucleic acids or SNAs) to control protein expression. These easily synthesized nanoparticles can have either DNA or RNA shells, and are less than 50 nm in hydrodynamic diameter. SNA co ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Human Induced Pluripotent Stem Cell-Derived Beta-Cells for Drug and Toxicity Testing

    SBC: Regenerative Medical Solutions Inc            Topic: NIDDK

    ? DESCRIPTION (provided by applicant): Diabetes represents one of the most serious health crises worldwide. It is estimated by the American Diabetes Association that one person is diagnosed with diabetes every 17 seconds, while the International Diabetes Federation states that one person dies every seven seconds from diabetes. Diabetes growth continues to skyrocket, with over 382 million cases ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. High-Throughput Microdevice for Temporal Single-Cell Analysis

    SBC: INFINITESIMAL, LLC            Topic: NIGMS

    DESCRIPTION: Single-cell studies are essential for biochemical characterization of heterogeneous cell behaviors. However, studying direct correlation between cell input (transfection) and output (biochemical analysis) is still challenging due to lack of high throughpu methodologies with cell selectivity and high enough sensitivity. The tool proposed here is a microwell device that will allow tempo ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Activated hexosamines from chitin for production of important oligosaccharides

    SBC: ZUCHEM INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): UDP-GlcNAc and UDP-GalNAc comprise the core structures of glycans in glycoproteins and glycolipids. Oligosaccharides containing N-acetyl-hexosamines involved in various biological process, including microbial infection,toxin entry, cancer cell metastasis. They are the key building blocks for human milk oligosaccharides, blood antigens, and other important oligo ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Novel Small Molecule Multi-targeted Ligands as Therapeutics for the Treatment of

    SBC: JASIN DISCOVERY SOLUTIONS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA), a common autosomal recessive motor neuron disorder is the leading genetic cause of infant mortality. SMA is caused by the loss of the survival motor neuron1 (SMN1) gene. SMN2, a nearly identical paralog, is present in all SMA patients but differs by a critical nucleotide that alters exon 7 splicing efficiency. This results in low ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. A proposal to develop a self-regulating hydromorphone tablet to deter excess oral

    SBC: ACURA PHARMACEUTICALS, INC.            Topic: NIDA

    DESCRIPTION: The medical misuse and non-medical use of prescription opioid analgesics is a significant problem in USA and its societal effects and cost have been well documented. The emergence of abuse deterrent opioid products into the marketplace is targeted to stem the advance of this complex problem. Although new abuse deterrent opioid products have been introduced which deter manipulation of ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Using an API to commercialize an evidence-based weight loss intervention

    SBC: COEUS HEALTH, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Over 69 percent of the U.S. population is currently overweight or obese; 35 percent are obese. Obesity is a primary cause of numerous chronic diseases including type II diabetes, cancer, heart disease and the metabolicsyndrome. Behavioral weight loss interventions have successfully resulted in significant clinical improvements in weight (7-10 percent weight los ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Topically-delivered Targeted Gene Suppression of Immune Activation in Psoriasis

    SBC: Exicure, Inc.            Topic: NIAMS

    DESCRIPTION (provided by applicant): AuraSense Therapeutics (AST), along with Northwestern University, is applying a recently developed technology using oligonucleotide-functionalized nanoparticles (called spherical nucleic acids or SNAs) to control protein expression. These easily synthesized nanoparticles can have either DNA or RNA shells, and are less than 50 nm in hydrodynamic diameter. SNA co ...

    STTR Phase I 2014 Department of Health and Human Services
  9. Engineering Cytolytic Effectors to Eliminate Virus-Infected and Cancer Cells

    SBC: IMMUVEN, INC.            Topic: NCI

    Project Summary The goal of this STTR grant application is to engineer powerful NK cell-based cytolytic effector cells for therapeutic applications. The cells will combine the selectivity and specificity of T cells and the ability of NK cells to mediate effective cytolytic activity against a wide spectrum of aberrant cells, including those with impaired adhesion properties. To achieve this goal we ...

    STTR Phase I 2014 Department of Health and Human Services
  10. Developing Therapeutics That Target RAD51 to Treat Leukemia and Lymphoma

    SBC: Cyteir Therapeutics, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Genomic instability is a hallmark of cancer, yet is underdeveloped as a therapeutic target area The central goal of this program is to develop new cancer therapeutics that target genomic instability as a hallmark of cancer cells, bringing new, cancer-cell selective treatments to the clinical oncology market. Two key challenges in current cancer therapy are mini ...

    STTR Phase I 2014 Department of Health and Human Services

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