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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of a Portable Microwave Atomic Clock Using Pulsed Coherent Population Trapping

    SBC: DIGITAL OPTICS TECHNOLOGIES INC            Topic: SB141004

    We propose to develop a low SWaP, portable microwave Rb-87 cold atomic clock using pulsed coherent population trapping (CPT). The SWaP goal is to achieve a volume of

    SBIR Phase I 2014 Department of DefenseDefense Advanced Research Projects Agency
  2. A Low-Cost, High-Performance Colloidal Quantum Dot MWIR Focal Plane Array

    SBC: SIVANANTHAN LABORATORIES, INC.            Topic: ST13B002

    The primary goal of this proposed effort is to develop mid-wavelength infrared (MWIR) colloidal quantum dot (CQD)-based focal plane arrays (FPAs) to significantly reduce the cost of MWIR photon imagers. In order to realize this goal, it will first be nec

    STTR Phase I 2014 Department of DefenseDefense Advanced Research Projects Agency
  3. Low Cost, Efficient Microchannel Plasma Ozone System for Point of Use Water Treatment

    SBC: EP Purification, Inc.            Topic: A

    A team at EP Purification has performed research for the development and commercialization of low-cost microchannel plasma reactor modules capable of efficiently producing ozone for water treatment and other environmental applications in a slim form factor and size. The conservation of water resources for human consumption is a growing national priority. Ozone is a unique purification agent as it ...

    SBIR Phase II 2014 Environmental Protection Agency
  4. Destroying the HIV-1 provirus by utilizing components of the CRISPR/Cas system

    SBC: CELDARA MEDICAL, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): The goal of this project is to develop a plasmid-based therapy that will destroy the integrated HIV-1 DNA (HIV- 1 provirus) in infected cells. Current HIV-1 anti-retroviral therapy (ARV) consists of a cocktail of drugsthat blocks viral binding and replication, but does not destroy the HIV-1 provirus. In addition, ARV does not impact the large reservoir of laten ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Topically-delivered Mutation-specific Gene Targeting for Epidermolytic Ichthyosis

    SBC: Exicure, Inc.            Topic: NIAMS

    DESCRIPTION (provided by applicant): AuraSense Therapeutics (AST), along with Northwestern University, is applying a recently developed technology using oligonucleotide-functionalized nanoparticles (called spherical nucleic acids or SNAs) to control protein expression. These easily synthesized nanoparticles can have either DNA or RNA shells, and are less than 50 nm in hydrodynamic diameter. SNA co ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Synergy between MAG-1 and Cyclophosphamide for Treatment of Recurrent SCLC

    SBC: Woomera Therapeutics, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): There is currently no effective treatment for recurrent small-cell lung cancer (rSCLC). The objective of this project is to utilize a monoclonal antibody, MAG-1, to develop new, rational, and successful treatment of rSCLC. The hypothesis being tested is that a cancer -specific provasopressin antigen, called GRSA, present at the surface of these tumors will prov ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Dampening CAR therapy-induced cytokine storm with anti-GM-CSF antibodies

    SBC: CELDARA MEDICAL, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): The long-term aim of this project is to reduce or eliminate the serious adverse events associated with cellular immunotherapy used to treat cancer. The current impressive efficacy of chimeric antigen receptor (CAR) T cell therapies is often accompanied by a well-known toxicity stemming from the large release of cytokines from activated immune cells, known as a ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Low-Cost User-Friendly Otoacoustic Emissions Probe

    SBC: CREARE LLC            Topic: NIDCD

    DESCRIPTION (provided by applicant): This proposal responds to the NIDCD special solicitation RFA-DC-12-004 for improving access to hearing healthcare. In particular, the NIDCD is seeking solutions to lower the cost of hearing healthcare and improve accessfor underserved populations (such as the disabled and communities with limited resource access). Technologies that achieve the initiative object ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Human Induced Pluripotent Stem Cell-Derived Beta-Cells for Drug and Toxicity Testing

    SBC: Regenerative Medical Solutions Inc            Topic: NIDDK

    ? DESCRIPTION (provided by applicant): Diabetes represents one of the most serious health crises worldwide. It is estimated by the American Diabetes Association that one person is diagnosed with diabetes every 17 seconds, while the International Diabetes Federation states that one person dies every seven seconds from diabetes. Diabetes growth continues to skyrocket, with over 382 million cases ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. High-Throughput Microdevice for Temporal Single-Cell Analysis

    SBC: INFINITESIMAL, LLC            Topic: NIGMS

    DESCRIPTION: Single-cell studies are essential for biochemical characterization of heterogeneous cell behaviors. However, studying direct correlation between cell input (transfection) and output (biochemical analysis) is still challenging due to lack of high throughpu methodologies with cell selectivity and high enough sensitivity. The tool proposed here is a microwell device that will allow tempo ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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