Award Data

PROJECT SUMMARY Therapy for Alzheimer’s disease and related dementias (AD/ADRD), slow-progressing neurodegenerative diseases, remains elusive. Therapeutic approaches focusing on beta amyloid (Aβ) removal from the brain or on targeting genes for which strong associations between their polymorphism and AD/ADRD are established, have had a mixed record of success. We propose a novel strategy to rev ...

DESCRIPTION (provided by applicant): ABC transporters pump a variety of small molecules and peptides across cell membranes. Mutations in ABC transporter genes cause severe defects in man. Drugs that modulate ABC transporter function would have utility as anti-microbials through inhibition of essential microbial ABC transporters, as well as in the states of atherosclerosis, macular degeneration, di ...

Abstract Deliriuma major cause of fallscan occur in as many asof cancer patients undergoing stem cell transplantationresulting in up totimes greater chance of dyingDelirium risk can be mitigated and many other outcomes of stem cell transplants can be improved through behavioral interventions delivered at the bedside through conversationimageryand audioHowevertraditional means of delivering these i ...

Abstract Delirium, a major cause of falls, can occur in as many as 50% of cancer patients undergoing stem celltransplantation, resulting in up to 14 times greater chance of dying. Delirium risk can be mitigated and manyother outcomes of stem cell transplants can be improved through behavioral interventions delivered at thebedside through conversation, imagery, and audio. However, traditional means ...

Project Summary Enabling high accuracy nanopore based strand sequencing has the potential to improve the understanding of long range genomic relationships and processes andbased on its accessibilityenable the associated clinical and diagnostic applicationsthe fastest growing sequencing sectorUnfortunatelyit is commonplace for nanopore sequencing error rates to exceedand higher accuracy is needed t ...

DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...

DESCRIPTION (provided by applicant): A closed loop, glucose sensing, and insulin responsive system could dramatically improve treatment options for insulin dependent diabetics. Current artificial systems, however, lack the ability to provide this precise control. Clinical islet transplantation, the intrahepatic loading of allogeneic islets, shows the potential to provide this intimate control, by ...

7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

The U.S. poultry industry produces more than 45 billion pounds of poultry annually. A majority of this production is from concentrated animal feeding operations. In a modern poultry growing facility, small chicks are raised in several large houses that typically cover over 20,000 ft2. Starting with each grow-out period, fresh wood mulch bedding material is spread over the house floor. Over the co ...

The U.S. poultry industry produces more than 45 billion pounds of poultry annually. A majority of this production is from concentrated animal feeding operations. In a modern poultry growing facility, small chicks are raised in several large “houses” that typically cover over 20,000 ft2. Starting with each grow-out period, fresh wood mulch bedding material is spread over the house floor. Ove ...