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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. DEVELOPMENT OF A SERUM-FREE MEDIUM FOR CELLS

    SBC: Biological Research Faculty &            Topic: N/A

    THE MAIN OBJECTIVE OF THIS PHASE I PROJECT WAS TO ESTABLISH A SOURCE OF SERUM-FREE MEDIUM SUITABLE FOR SUSTAINED GROWTH OF EARLY PASSAGE SYRIAN HAMSTER EMBRYO (SHE) CELLS. SPECIFIC AIMS INCLUDED SELECTION OF A BASAL MEDIUM SUPPORTIVE OF CLONAL GROWTH IN LIMITING SERUM CONCENTRATIONS, REPLACEMENT OF SERUM BY SELECTED GROWTH FACTORS AND HORMONES, OPTIMIZATION OF SUPPLEMENTS BY CLONAL TITRATIONS, AND ...

    SBIR Phase II 1990 Department of Health and Human Services
  2. CULTURE DISHES WITH UNIQUE SURFACES

    SBC: Biomedical Development Corporation            Topic: N/A

    THE PURPOSE OF THIS RESEARCH IS TO FABRICATE AND TEST THE EFFICACY OF CULTURE DISHES WITH UNIQUE SURFACES. THIN FILMSOF METAL, METAL ALLOYS AND CERAMICS WILL BE APPLIED TO STANDARD POLYSTYRENE CULTURE DISHES. GROWTH OF FIBROBLAST AND OSTEOBLAST CELL LINES ON THE CULTURE PLATES WILL SERVE AS MODELS OF SOFT TISSUE AND HARD TISSUE MAMMALIAN CELLS. CELL MORPHOLOGY AND GROWTH WILL BE MONITORED BY PHASE ...

    SBIR Phase II 1990 Department of Health and Human Services
  3. FREEZING DRYING AND REHYDRATION OF MAMMALIAN CELLS

    SBC: LIFECELL CORPORATION            Topic: N/A

    TO DEMONSTRATE THAT CULTURED MAMMALIAN CELLS CAN BE FROZEN, DRIED, REHYDRATED, AND REVIVIFIED, FOUR CELL LINES WERE CHOSEN FOR EXPERIMENTS THAT WILL DETERMINE: (1) THE OPTIMUM METHOD OF CELL VITRIFICATION (FREEZING WITHOUT ICE CRYSTALS)AND WHETHER CRYOPROTECTION IS NECESSARY, (2) WHETHER DRYING PROTECTION IS NEEDED, (3) HOW TO MAKE DRYING COMPATIBLE WITHTHE NATURE OF THE CELL, (4) WHETHER UNIFORMI ...

    SBIR Phase II 1990 Department of Health and Human Services
  4. REGISTERS OF INHERITED METABOLIC DISEASES

    SBC: Mize Information Enterprise            Topic: N/A

    THE OBJECTIVES OF THIS PROJECT ARE TO ESTABLISH A REGISTER OF INHERITED METABOLIC DISEASES (IMD'S) THAT WILL PROVIDE DATA FOR APPROPRIATE HEALTH-CARE PROVIDERS TO IDENTIFY, CLASSIFY, AND TRACK PATIENTS WITH IMD'S. THE METHODOLOGY DEVELOPED TO IMPLEMENT AS ACCURATE AND COMPLETE REGISTER INFORMATION AS POSSIBLE ON TWO IMD'S (GALACTOSEMIA AND MSUD)WILL BE TRANSFERRABLE TO OTHER DISEASES. TASKS INCLUD ...

    SBIR Phase II 1990 Department of Health and Human Services
  5. TRUE-COLOR IMAGE WORKSTATION FOR PATHOLOGY RESEARCH

    SBC: POTOMAC MEDICAL SYSTEMS            Topic: N/A

    UNTIL NOW, THE BENEFITS OF COMPUTERIZATION HAVE NOT SPREAD TO IMAGE-BASED FIELDS SUCH AS PATHOLOGY. ALTHOUGH A FEW EXPENSIVE IMAGE-PROCESSING COMPUTER SYSTEMS HAVE BEEN USED FOR PATHOLOGY RESEARCH, AFFORDABLE, GENERAL-PURPOSE SYSTEMS HAVE BEEN UNAVAILABLE. IMAGE PROCESSING HAS BEEN LIMITED TO BLACK-AND-WHITE IMAGES. RECENT PROGRESS IN MICROCOMPUTERIMAGE-PROCESSING HARDWARE WILL NOW ALLOW THE PRODU ...

    SBIR Phase II 1990 Department of Health and Human Services
  6. ANTI-IDIOTYPIC VACCINES FOR AIDS

    SBC: TANOX, INC.            Topic: N/A

    THE GEOMETRIC INCREASE IN THE NUMBER OF INDIVIDUALS INFECTED BY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) HAS CREATED SERIOUS SOCIAL, ECONOMICAL AND LIFE-THREATENING ISSUES TO THE HUMAN RACE. IT IS OF PRESSING CONCERNS TO DEVELOP EFFECTIVE MEASURES FOR CONTROLLING THE SPREAD OF THIS DISEASE, FAVORABLY BY INDUCING ACTIVE IMMUNITY TO THE INDIVIDUALS AT RISK TO THE INFECTION. BASED ON THE PHENOMENA ...

    SBIR Phase II 1990 Department of Health and Human Services
  7. EVALUATION OF WORKSITE HEALTH PROMOTION MATERIALS

    SBC: The Kbl Group Inc            Topic: N/A

    THE BROAD GOAL OF THIS PROJECT IS TO DEVELOP AN EVALUATION SYSTEM THAT IDENTIFIES, CATALOGS, AND ASSESSES THE QUALITY OF MATERIALS DESIGNED FOR USE IN WORKSITE HEALTH PROMOTION PROGRAMS IN THE AREAS OF NUTRITION AND WEIGHT LOSS, SMOKING CESSATION, AND CANCER SCREENING. SPECIFIC OBJECTIVES OF PHASE I INCLUDE: (1) CONDUCTING A NEEDS ASSESSMENT; (2) IDENTIFYING AND COLLECTING WORKSITE MATERIALS ON NU ...

    SBIR Phase II 1990 Department of Health and Human Services
  8. DEVELOPMENT OF A LOW COST ACR-NEMA PACS INTERFACE

    SBC: Dejarnette Research Systems            Topic: N/A

    THE PURPOSE OF THE PROPOSED RESEARCH AND DEVELOPMENT EFFORT IS TO DEVELOP A LOW COST/GENERAL PURPOSE ACR-NEMA PACS INTERFACE. THE LONG TERM GOAL OF THIS EFFORT IS THE DEVELOPMENT OF AN APPLICATION SPECIFIC INTEGRATED CIRCUIT (ASIC) IMPLEMENTATION OF THE ACR-NEMA INTERFACE STANDARD. THIS ASIC WOULD CONTAIN THE INTERFACE TRANSCEIVERS AND THE LOGIC TO IMPLEMENT THE PHYSICAL AND DATALINK LAYERS OF THE ...

    SBIR Phase II 1990 Department of Health and Human Services
  9. BRAIN IMAGING QUANTITATION TECHNIQUES

    SBC: Loats Associates, Inc.            Topic: N/A

    THE GOAL OF THIS PHASE I EFFORT IS TO DEVELOP AND VALIDATE A CAPABILITY FOR QUANTITATIVE ANALYSIS AND DISPLAY OF CT, MRI, AND ECT IMAGES OF THE BRAIN. WE PROPOSE TO DEVELOP AND VALIDATE THE OVERALL APPROACH OF MULTI-MODAL IMAGE REGISTRATION AND DISPLAY OF THE IMAGES, FILTERING OF ECT DATA TO SIMULTANEOUSLY ENHANCE RESOLUTION AND REDUCE NOISE, AND TECHNIQUES TO GENERATE PRECISE QUANTITATION OF TWO ...

    SBIR Phase II 1990 Department of Health and Human Services
  10. DEVELOPMENT OF A CLINICIAN'S INFORMATION SYSTEM

    SBC: Civilized Software, Inc.            Topic: N/A

    THE RESEARCH PROPOSED IS TO INVESTIGATE THE FEASIBILITY OF WRITING A SOFTWARE PACKAGE FOR PERSONAL WORKSTATIONS THAT WILL HELP CLINICAL RESEARCHERS AND THEIR ASSISTANTS CARRY OUT THE DESIGN, DATA COLLECTION, DATA STORAGE, AND FORMAL AND EXPLORATORY ANALYSES OF CLINICAL TRIALS. THE PURPOSE OF SUCH SOFTWARE WILL BE TO ASSIST THE SINGLE RESEARCHER OR THE SMALL GROUP DOING SMALL- TO MODERATE-SIZED TRI ...

    SBIR Phase II 1990 Department of Health and Human Services

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