Award Data

THE GOAL OF THIS PHASE I RESEARCH IS TO DESIGN, SYNTHESIZE, DEVELOP, AND EVALUATE THE IN VITRO EFFICACY OF A NEW CLASS OF POLYMERIC "TARGETED" PRODRUGS OF AZT. THE OVERALL OBJECTIVE OF THIS PROGRAM IS TO CREATE NEW ANTI-AIDS PRODRUGS THAT WILL POSSESS MARKEDLY ENHANCED ANTIVIRAL ACTIVITY, LOW TOXICITY, TARGET ACCESSIBILITY, AND SUSTAINED DRUG RELEASE. THE PHASE I PLAN IS BASED ON THE PROMISING IN ...

THE OVERALL OBJECTIVE IS TO PROVIDE A NEW DRUG DELIVERY SYSTEM AND TO ENHANCE THE SOLUBILITY OF EXISTING COMPOUNDS THAT EXHIBIT EXCELLENT ANTITUMOR PROPERTIES BUT ARE INSOLUBLE IN WATER. AQUEOUS SOLUBILITY IS ESSENTIAL FOR I.V. ADMINISTRATION OF ANTITUMOR DRUGS. PHASE I RESEARCH WILL SOLUBILIZE DIAMMINEPLATINUMHYDROXYMALONATE AND (TRANS-1,2-DIAMINOCYCLOHEXANE) PLATINUMHYDROXYMALONATE COMPLEXES BY ...

IT IS PLANNED TO DEVELOP A LASER PLUME ANALYSIS INSTRUMENTATION SYSTEM THAT IS SUITABLE FOR QUANTITATIVE MEASUREMENTS ON POTENTIALLY HARMFUL TISSUE ABLATION BY-PRODUCTS SUCH AS TOXIC VAPOR SPECIES IN LASER PLUMES GENERATED BY LASER SURGERY PROCEDURES. IN PHASE I, CANDIDATE LASER PLUME ANALYSIS INSTRUMENTS WILL BE EVALUATEDFOR THEIR UTILITY IN MEASURING TISSUE ABLATION BY-PRODUCTS PRODUCED BY ARGON ...

CHROMIUM DEFICIENCY CAUSES SEVERE INSULIN RESISTANCE AND GLUCOSE INTOLERANCE. AVERAGE DIETARY CHROMIUM INTAKE IN THEUNITED STATES AND OTHER DEVELOPED COUNTRIES IS MARGINAL AND MAY CONTRIBUTE TO THE HIGH FREQUENCY OF DIABETES PLAGUING DEVELOPED COUNTRIES. THE MAJOR CLINICAL CHROMIUM EVALUATIONPROBLEM IS THE ASSESSMENT OF CHROMIUM STATUS. DETERMINATIONOF CHROMIUM STATUS HAS BEEN DIFFICULT BECAUSE OF ...

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A NEW COMPUTER SOFTWARE PACKAGE TO PERFORM AUTOMATIC INTERACTIONS DETECTION (AID). THIS TECHNIQUE WAS THE CORNERSTONE OF THE DEVELOPMENT OF THE MEDICARE PROGRAM'S DIAGNOSIS RELATED GROUPS AND HAS BEEN WIDELY USED IN THE DEVELOPMENT OF CASE MIX CLASSIFICATION SYSTEMS AND OTHER RESEARCH. THE SOFTWARE WILL BE DESIGNED TO REMEDY THE MANY SHORTCOMIN ...

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THE MAIN OBJECTIVE OF THIS PHASE I PROJECT WAS TO ESTABLISH A SOURCE OF SERUM-FREE MEDIUM SUITABLE FOR SUSTAINED GROWTH OF EARLY PASSAGE SYRIAN HAMSTER EMBRYO (SHE) CELLS. SPECIFIC AIMS INCLUDED SELECTION OF A BASAL MEDIUM SUPPORTIVE OF CLONAL GROWTH IN LIMITING SERUM CONCENTRATIONS, REPLACEMENT OF SERUM BY SELECTED GROWTH FACTORS AND HORMONES, OPTIMIZATION OF SUPPLEMENTS BY CLONAL TITRATIONS, AND ...

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THE PURPOSE OF THIS RESEARCH IS TO FABRICATE AND TEST THE EFFICACY OF CULTURE DISHES WITH UNIQUE SURFACES. THIN FILMSOF METAL, METAL ALLOYS AND CERAMICS WILL BE APPLIED TO STANDARD POLYSTYRENE CULTURE DISHES. GROWTH OF FIBROBLAST AND OSTEOBLAST CELL LINES ON THE CULTURE PLATES WILL SERVE AS MODELS OF SOFT TISSUE AND HARD TISSUE MAMMALIAN CELLS. CELL MORPHOLOGY AND GROWTH WILL BE MONITORED BY PHASE ...

ROTATIONAL PANORAMIC RADIOGRAPHY IS A WELL-ESTABLISHED RADIOGRAPHIC TECHNIQUE THAT IS WIDELY USED IN DENTISTRY. THIS TECHNIQUE DISPLAYS THE ENTIRE MAXILLOMANDIBULAR REGION ON A SINGLE FILM. WITH THE DEVELOPMENT OF DIGITAL COMPUTERS AND SUITABLE RADIATION DETECTORS, IT HAS BECOME POSSIBLE TO DEVELOP DIGITAL SYSTEMS FOR THE RECORDING AND DISPLAY OF X-RAY IMAGES. THE PURPOSE OF THIS RESEARCH IS TO EV ...