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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A microchip to analyze trafficking leukocytes in Alzheimer’s disease patients

    SBC: ISOPLEXIS CORPORATION            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD is one of the most common neurodegenerative diseases that lead to detrimental outcomes such as progressive memory deficit and cognitive impairment Although it is expected that the prevalence of AD will double over the next years currently no widely accepted molecular biomarkers for early detection or non invasive monitoring ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Fungal Metabolites Fuel Drug Discovery for Pathogenic Free-Living Amoebae

    SBC: Mycosynthetix, Inc.            Topic: R

    DESCRIPTION provided by applicant Small free living amoebae FLA are ubiquitous in nature and are found in soil fresh water and marine environments Most FLA feed on bacteria and are of no medical importance yet several FLA are known to cause serious usually fatal disease in humans and animals Naegleria fowleri and Acanthamoeba spp are the best known examples of pathogenic FLA N fowle ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Device for rapid extraction of rare pathogens from raw samples

    SBC: Redbud Labs, Inc.            Topic: NIAID

    of Hospital acquired infection that leads to sepsis is deadly expensive and increasingly common Rapid diagnosis anti microbial treatment and identification of the pathogen strain is key to improving outcomes and reducing costs Diagnosis and strain identification must improve Novel techniques for blood culture BC and molecular diagnostics MDx are promising but better technology for pa ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. A RAPID ASSAY FOR DETECTION OF DETECTION OF CARBAPENEMASE PRODUCING ORGANISMS

    SBC: CELLEX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant A recent outbreak of carbapenem resistant Enterobacteriaceae CRE associated with contaminated duodenoscopes at the Ronald Reagan UCLA Medical Center highlights the importance of early detection of these clinically significant pathogens Coincidentally the Obama Administration released The National Action Plan to Combat Antibiotic Resistant Bacteria for which ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Low Temperature Sterilization Method for Flexible Endoscopes

    SBC: Brighton Development            Topic: R

    DESCRIPTION provided by applicant Healthcare associated infections HAI are the single largest preventable medical cost in terms of both economic and humanitarian cost The significance of this problem is reflected in the $ billion annual expenditure made for healthcare associated infections in the medical community Due to the large number of procedures done each year endoscopes are associ ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Novel technologies for improved slide quality of pancreatic fine-needle aspirates

    SBC: AFFINERGY, LLC            Topic: 300

    DESCRIPTION provided by applicant Endoscopic ultrasound guided fine needle aspiration biopsy is the standard technique for diagnosis and staging of suspicious pancreatic lesions Unfortunately blood and other unwanted debris are frequently present in these fine needle aspirates thus diluting and obscuring cells of interest Subsequent slide preparations from such aspirates are suboptimal lea ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Rapid manufacturing of recombinant nucleosomes for high-throughput assays

    SBC: Epicypher, Inc.            Topic: 100

    DESCRIPTION provided by applicant Chromosomes are composed of genomic DNA and associated protein components that exert powerful regulatory effects The nm nucleosome represents the functional unit of chromatin comprising turns of genomic DNA bp wrapping an octamer of histone proteins Post translational modification PTM of the histones e g methylation acetylation or ubiquiti ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Low Cost Microphysiological System for Improved Pharmacodynamics

    SBC: SCIKON INNOVATION, INC.            Topic: 300

    DESCRIPTION provided by applicant The high failure rate of drugs in late stage development nearly is a symptom of the inadequacy of pre clinical animal models to accurately predict human biology One of the major reasons drugs fail in the clinic is inaccurate prediction of the therapeutic index which is the dose range where drugs are effective and also not toxic Failure to identify meta ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Novel tools for site-specific ablation of the mitochondrial genome

    SBC: ENZERNA BIOSCIENCES LLC            Topic: 200

    DESCRIPTION provided by applicant Millions of individuals are affected by diseases caused by mutations in mitochondrial encoded genes which lead to a diverse set of clinical disorders ranging from visual impairment optic neuropathy to accelerated aging to hypertrophic cardiomyopathy Unfortunately there are no commercially available technologies that can enable investigators to dissect the f ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Advancing Human Health by Lowering Barriers to Electrophysiology in Genetic Model Organisms

    SBC: NEMAMETRIX, INC            Topic: 300

    DESCRIPTION provided by applicant The nematode Caenorhabditis elegans is a powerful experimental system that is widely used as a model for a large number of high impact medical conditions from aging and metabolic disorders to neurodegenerative diseases The strength of this microscopic worm as a medical model derives from the extensive genetic homology between nematodes and humans together ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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