Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Silver coatings to combat catheter associated infections

    SBC: ACRYMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Abstract Indwelling catheterization is a leading cause of nosocomial infections that present an enormous drain of health care funding in the US. Clinical infections associated with urinary catheterization have been estimated to add more than $1000 to patient care. Those that occur with central venous catheterization escalate the cost to between $35,000 and $50, ...

    SBIR Phase I 2006 Department of Health and Human Services
  2. Nanoliter Lab-on-a-chip for Protein Crystallization

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): The human genome contains at least 30,000 unique open reading frames that may yield >100,000 polypeptide products. These products assemble into more than a million biologically relevant structures or proteins of interest per organism. Crystallization and X-ray diffraction of these proteins is routinely performed to determine their 3D structure which needs to be ...

    SBIR Phase II 2006 Department of Health and Human Services
  3. Nanoliter Lab-on-a-Chip for Blood Diagnostics

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Latrogenic blood loss or "bleeding into the laboratory" is an important reason for administration of small volume transfusions in very low birth weight premature 6infants. A direct correlation was found between the volume of blood drawn for diagnostics and subsequent volume transfused. In neonatal infants, there may not be enough collected blood sample to perfo ...

    SBIR Phase II 2006 Department of Health and Human Services
  4. Nanoliter Lab-on-a-Chip for Rapid Parallel Immunoassays

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): The development of clinically effective cancer vaccines requires reliable analytical methods to evaluate the immune response to vaccination. Immunoassays are among the most sensitive and specific analytical methods that have been used widely in cancer vaccine research, most commonly to monitor the release of cytokines from T-cells in response to vaccination. A ...

    SBIR Phase I 2006 Department of Health and Human Services
  5. Discovery of a Platelet Derived Growth Factor Peptide-based Mimetic

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Summary/Abstract Diabetic foot ulcers are a significant health problem that imposes high costs on both patients and society (Boulton, Vileikyte et al. 2005). A large proportion of foot ulcers remain unresponsive to available conventional treatment and their associated complications and costs have prompted extensive research that has led to promising breakthroug ...

    SBIR Phase I 2006 Department of Health and Human Services
  6. Click Chemistry for Immobilized Bone Morphogenetic Protein

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There are over 6.3 million fractures each year in the United States of which approximately 700,000 are difficult to heal. The available treatment options for fractures that do not heal or are slow to heal are limited. Bone morphogenetic proteins are growth factors that stimulate new bone production and have received FDA approval for bone fracture repair and spi ...

    SBIR Phase I 2006 Department of Health and Human Services
  7. Improved Orthopedic Implant Surface Coatings

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Many contemporary medical and dental therapies include the replacement or repair of tissues using materials such as metal. Currently there are at least 150,000 hip replacements, 300,000 knee replacements, and 500,000 dental implant procedures performed in the US each year (Kurtz, Mowat et al. 2005). These numbers are expected to increase as the baby boom gen ...

    SBIR Phase II 2006 Department of Health and Human Services
  8. Injectable BMP-2 Formulation for Fracture Healing

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Two recombinant human Bone Morphogenetic Proteins (BMP's), rhBMP-2 and rhBMP-7, are currently used in clinical applications to promote spinal fusion and fracture healing (Mont, Ragland et al. 2004). Over 6.3 million fractures occur each year in the United States alone (Praemer, Furner et al. 1999). Approximately 15% of fractures have delayed or impaired healing ...

    SBIR Phase I 2006 Department of Health and Human Services
  9. Growth Factor Coated Sutures for Improved Tendons Repair

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Tendon injuries are quite common and the frequency of these injuries is expected to rise as the population ages, yet continues to remain active. Long periods of immobilization and rehabilitation are required because tendon healing is a relatively slow process. Innovations that can shorten this time period by improving healing rates and increasing the strength o ...

    SBIR Phase I 2006 Department of Health and Human Services
  10. High-throughput Prediction of Compound Tissue Distribution

    SBC: ANALYTICAL BIOLOGICAL SERVICES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of the proposed research is to develop tools for the prediction of the distribution of drug compounds in the human body. There is currently no experimental high throughput screening (HTS) method for determining compound tissue distribution. A drug compound's propensity to be taken up by different tissues and organs affects whether it will reach its acti ...

    SBIR Phase I 2006 Department of Health and Human Services
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