Award Data

Advanced Liquid Logic proposes to develop a very capable analyzer based on its digital microfluidic technology. Such an analyzer would be:  Capable of both simple and complex biological assays  Small, lightweight, power efficient, and easy to operate  Fully programmable and remotely reprogrammable Under NIH funding we have demonstrated clinical chemistry blood diagnostic testing on our ...

We propose to continue the development and characterization of a polymeric nanoencapsulation technology that can increase the lifetime of a protein therapeutic agent within a biological system. The materials have been demonstrated to exhibit no cytotoxicity and to efficiently deliver antibody against Protective Antigen of bacillus anthracis.

We propose that a comparative colorimetric assay be developed that will use a ticket of the same dimensions as the current ANP immunoassay tickets. This will allow the AChE test to be conducted using a similar workflow as the lateral flow immunoassay-based HHAs and be similarly read on the ANP reader to yield an unambiguous result independent of user judgment.

Low-light-level photodetector arrays are proposed for detecting the weak optical emission spectra from the trace atoms in the laser-induced breakdown spectroscopy (LIBS). The proposed semiconductor image intensifier and low-light-level camera utilize the miniaturized and monolithically integrated version of a proven solid-state detector technology, and is expected to be able to detect femto-watts ...

The objective of this proposal is to improve the computational tools identified in Phase 1 that will be useful in assessing rocket and missile propulsion systems for compliance with insensitive munitions (IM) requirements. Comprehensive testing to ascertain IM compliance for such systems is time-consuming and expensive. High-fidelity computational tools exist that can be used to address the asse ...

Range surveillance is a critical component of space exploration because of its implications on safety, cost, and overall mission timeline. However, launch delays, due to the difficulty of verifying a cleared range, are common and will increase as spaceports are developed in new areas. In order to expedite range clearance, it is vital to see "through" the atmosphere. Unfortunately, the quality ...

NovaSol proposes to develop an advanced hyperspectral imaging system for earth science missions named BRASS (Broadband Advanced Spectral System). BRASS combines state-of-the-art, existing NASA detector technology and proven electronics with a novel spectrometer design to provide a compact instrument that covers the full wavelength range from 0.4 to 5 ?m. Applications for such an instrument range f ...

Plant chloroplasts are capable of producing significant quantities of high quality bioengineered proteins with biomedical applications. Improving the commercial supply of diagnostic antigens and vaccines through use of our pliable expression platform will provide an important technological advance compared with the current mammalian and microbial cell culture platforms. Our innovative approach c ...

There is a need for lightweight high-density (4000+ lines/mm) novel diffraction grating elements in modern telescopes to advance EUV and X-ray astrophysics. Current grating technologies (ruling and holographic beam interference) do not provide optimal solution for all grating requirements. In response to NASA request, we propose to apply state-of-the art DUV reduction photolithographic tools dev ...

The innovation in this project is model-based design (MBD) tools for predicting the performance and useful life of commercial-off-the-shelf (COTS) components and COTS-based systems beyond their rated temperature range. Phase I results have shown the feasibility of these tools, which consist of novel modeling tools and advanced system and data analysis capability. The modeling tools differ from all ...