Award Data

Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme acetylcholinesterase (AChE); the resulting excess acetylcholine accumulates and overstimulates the human or animal bo ...

This Phase 2 project targets the completion of the development of an improved system for the broadcasting of the WWVB signal, as a direct continuation of the Phase 1 project, which successfully validated the proposed approach through a feasibility study and analyses. Objectives of this project include the design of the new modulation scheme and protocol, the development of a new time-code generato ...

Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram-negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect ...

This Phase I project will evaluate the feasibility of a pharmaceutical spray quality audit system. The spray quality audit system will estimate the mass distribution of active ingredients and droplet sizes in pharmaceutical sprays using combined fluorescence absorption and light extinction tomography. En’Urga will modify an existing instrument to simultaneously obtain full volume fluorescence ab ...

Nanometrology International, Inc. (NMI) proposes to demonstrate the feasibility of 3-dimensional (3D) characterization of nanoscale objects using scanning probe microscopy (SPM) with a measurement uncertainty of less than 0.7 nm. To accomplish this task, we propose a novel method of 3D tip characterization and use of an innovative surface reconstruction algorithm recently introduced by NIST and th ...

Domestic US aquaculture is moving toward fishmeal replacement in aquafeeds with a variety of alternative protein sources including plant-based, terrestrial and marine proteins. In our Phase I work we showed the feasibility of modifying the protein quality of several alternate protein sources, specifically animal byproduct meals, and its potential significant impacts on marine fish production. Th ...

We aim to create a low-cost, high-sensitivity hand-held plasmonic biosensor capable of sensing biotoxins. We will do this by using newly developed biodesign technology to create a new class of proteins which have an orders-of-magnitude increase in SPR signal-to-noise. These will be incorporated into a novel SPR device in which the transmission of light is affected by the binding of a particular t ...

Currently, the accepted standard experimental model for measuring protective efficacy against botulism is the Mouse Lethality Neutralization (MLN) assay. Botulism poisoning is a life threatening condition that is not only a public health concern, but could also be a potential biological weapon. With seven serotypes of botulinum neurotoxins, there is need for an alternative to the MLN assay due t ...

We propose a metamaterial-enhanced microbolometer with strong absorption over a narrow band that is dynamically tunable over the 8-10 micron band. A single-layer photonic metamaterial consisting of a thin metal film perforated with a 2-D array of dielectric apertures will be deposited on an amorphous-Silicon layer acting as an absorber and bolometer. The metamaterial, in conjunction with planar di ...

Identification of organophosphates (OPs) based nerve agents, is vital to the protection of U.S. armed forces personnel. Existing detection methods use bulky and expensive laboratory equipment, negating their battlefield use. Colorimetric indicators such as the currently deployed M8 and M9 detection papers are the fastest, cheapest, and easiest type of detector to use; however, these cannot detect ...