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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Bottom Feeder- A Highly Maneuverable Autonomous Underwater Vehicle

    SBC: Tridentis Advanced Marine Vehicles LLC            Topic: 822

    The Bottom Feeder project is designed to prove out the research done in Phase I using a prototype platform. The prototype will be a full size version of the platform designed during Phase I. The Phase I platform was designed to work in two operational configurations, a highly efficient mode and a highly maneuverable mode, with the ability to switch between them while submerged. The platform is equ ...

    SBIR Phase II 2019 Department of CommerceNational Oceanic and Atmospheric Administration
  2. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Whole-organ bioreactor with integrated nondestructive 3D molecular imaging

    SBC: Sonovol, Inc.            Topic: NHLBI

    Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. High Throughput CRISPR/Cas9 cell line generation using the CellRaft Array

    SBC: Cell Microsystems, Inc.            Topic: 400

    Project SummaryGenome editing technologiessuch as CRISPR Casprovide a rapidand targeted means of both knocking out gene expression and knocking in gene modificationsSince our initial Phase I submissionthe utility of CRISPR technology has expanded beyond the generation of cell linesto forward genetic screeningin vivo manipulation of gene expression and even human therapeuticsPhase I efforts success ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Software for predicting a drug's potential to cause acute kidney injury

    SBC: DILIsym Services, Inc.            Topic: 400

    The goal of this project is to develop novel technology for predicting drug induced kidney injury such as caused by systemic antimicrobialsdiureticsanticancer agentsand anti inflammatory drugsDrugs cause approximatelypercent of communityand hospitalacquired episodes of acute renal failurebut the incidence in older adults may be as high aspercentA significant problem is that while there are many dr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies

    SBC: IsoPlexis            Topic: NCI

    While CAR T therapies have advanced in the clinicthere are still two specific issues using these breakthrough therapies for blood cancersDurable responses in patients are only atand Cytokine Release Syndrome occurs inof treated patientsThese limitationsfor a drug that costs as much as $may cost an additional $for treating adverse events leading to caution for many clinical centers to administer th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a New Carbohydrate-based Anticoagulant Drug

    SBC: Glycan Therapeutics LLC            Topic: NHLBI

    Low molecular weight heparinsLMWHsare partially depolymerized natural products of heparinwhich are isolated from porcine intestineA worldwide distribution of contaminated heparin inwas associated withdeaths in the USThis crisis revealed the vulnerability of the LMWH supply chainLMWHs are complex mixtureshaving average molecular masses ofDaltonscorresponding tosaccharide unitsThe efficient preparat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Low cost retinal optical coherence tomography for point of care use

    SBC: Lumedica, Inc            Topic: NEI

    The objective of this research is to create a clinical prototype of a new optical coherence tomographyOCTsystem suitable for diagnostic retinal imaging at the point of careThe target system price will be one third the price of currently available research OCT systems while providing performance comparable to other entry level OCT imaging systemsBy breaking the $system barrier we will provide an in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Comprehensive Newborn Screening Solution for Duchenne and Congenital Muscular Dystrophies

    SBC: Baebies, Inc.            Topic: NICHD

    Congenital genetic abnormalities are a leading cause of childhood mortality and morbidityWhile routine newborn screeningNBShas dramatically improved health outcomesmany congenital disorders such as Duchenne muscular dystrophyDMDand other congenital muscular dystrophiesCMDare not currently detected by routine NBSPresymptomatic identification through NBS is critical to facilitate earlier initiation ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions

    SBC: Baebies, Inc.            Topic: NICHD

    An estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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