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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Tuned stem cell extracellular vesicles are a novel chronic wound therapeutic

    SBC: Zen-Bio, Inc.            Topic: NIA

    Project Summary The elderly population is rapidly increasing worldwide and those over 60 years old are expected to comprise 20% of the total population by 2050. These demographic changes will focus healthcare needs on those conditions more prevalent in the elderly. Chronic wounds, such as venous leg ulcers, pressure ulcers and diabetic ulcers are over-represented in the elderly population and even ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Increased sensitivity of minimal residual disease monitoring using peripheral blood in pediatric patients with acute lymphoblastic leukemia

    SBC: BIOFLUIDICA, INC.            Topic: 102

    Abstract Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood and accounts for approximately 30% of all cancers diagnosed before the age of 18 years (1). The primary cause of death for ALL patients is disease relapse. Therefore, monitoring for minimal residual disease (MRD) is considered the most powerful predictor of outcome in acute leukemias, including B-type acu ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. ALow Blood Volume Platform for Global Newborn Screening of Common, Treatable Conditions

    SBC: BAEBIES, INC.            Topic: NICHD

    An estimated 80% of babies born worldwide (approximately 100 million each year) currently do not receive any newborn screening care. Newborn screening (NBS) is an immensely successful testing program that identifies those at increased risk for common, treatable congenital disorders; the pre-symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and red ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Co-culture cassette for anaerobes and primary human intestinal epithelium

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project SummaryThe human colon is a remarkable organ, playing critical roles in drug uptake and metabolism as well as harboring the 100 trillion microbial cells of the microbiome, which itself has multiple impacts on human health. For these reasons, there is a widespread need in academia and the biotechnology marketplace for in vitro studies of human colon physiology and the interaction between co ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. BurntOut: Role-Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    PROJECT DESCRIPTIONBurntOut: Role-Play Simulation for Building Medical Student Resiliency Medical student and physician burnout rates are high. Rates correlate with alcohol and other substance use problems, and negatively impact patient care. This project will create a 3D simulation BurntOut: Role- Play Simulation for medical students to practice and respond to stressful situations, enhance coping ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Selection and preclinical development of a bacteria-targeting, non-antibiotic lead candidate to improve cancer chemotherapy outcomes

    SBC: SYMBERIX, INC.            Topic: 102

    The long-term objective of this project is a therapeutic adjunct to prevent chemotherapy-induced diarrhea (CID) based on a completely new mechanism of action targeting enteric bacteria. This Fast-Track SBIR proposal outlines the strategy for selecting a lead development candidate to be evaluated in investigational new drug (IND)-enabling studies to support a first-in-human trial. The focus of this ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of an oral therapeutic to mimic the anti-diabetic effects of gastric bypass surgery

    SBC: BIOKIER, INC.            Topic: 200

    SUMMARY Glucose homeostasis and food intake are both regulated by gut hormones secreted from enteroendocrine L- cells in the lower gut following stimulation by nutrients. This process is impaired in diabetes but is restored with delivery of dietary nutrients such as amino acids and fatty acids to the lower gut, such as after gastric bypass surgery and during fermentation of carbohydrates in the co ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Multiplex Platform for Point-of-Care Newborn Screening of Hyperbilirubinemia

    SBC: BAEBIES, INC.            Topic: NICHD

    ABSTRACT Multiplex Platform for Point-of-Care Newborn Screening of Hyperbilirubinemia (SBIR Phase IIB) Hyperbilirubinemia (jaundice) affects more than half of all newborns and is typically benign if identified and treated promptly. Without proper treatment, high bilirubin leads to serious neurological dysfunction including neuro-motor, auditory, speech, cognition, and language disturbances. Rapid ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Cross-Protective Multivalent Vaccine for Tick-Borne Flaviviruses

    SBC: HAWAII BIOTECH, INC.            Topic: NIAID

    Project Summary/AbstractThe NIH/NIAID 2017 Strategic Plan is specifically directed at promoting research that can provide solutions to mitigate the threat posed by emerging and re-emerging diseases. The tick-borne flavivirus (TBFV) group includes a number of important human pathogens that result in serious neurological or hemorrhagic diseases that are either Category B or C priority pathogens. The ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Novel enzyme inhibitor screening platform using modified designer nucleosomes

    SBC: Epicypher, Inc.            Topic: 300

    PROJECT SUMMARYChromatin function is regulated by reversible histone post-translational modifications (PTMs), including lysine methylation, acetylation, and monoubiquitination. Evidence places histone monoubiquitination (ub1) upstream of other chromatin PTMs, acting as a critical signaling center that regulates cascades of downstream epigenetic enzymes (e.g. histone methyltransferase enzymes or HM ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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