Award Data

DESCRIPTION provided by applicant Traumatic brain injury TBI is a leading cause of morbidity and mortality especially when complicated by secondary insults such as hypotension Vulnerability of TBI patients to hypotension is well recognized and identifies a key need for new approaches The goal of this proposal is to develop to IND a neuroprotective hyper colloid oxygen therapeutic polynit ...

DESCRIPTION provided by applicant X ray tricontrast imaging provides three different modes of contrast absorption contrast the mechanism behind how conventional medical X ray imaging equipment images phase contrast which provides up to X more contrast than absorption based contrast for soft tissue and scatter contrast which provides information of features at dimensions smaller than ...

DESCRIPTION provided by applicant In the andquot Enhancing Confidentiality of Research Files Based on Medicare Dataandquot project Acumen LLC aims to expand the overall capabilities of researchers to use survey linked Medicare claims data Currently the process for obtaining approval from the Centers for Medicare andamp Medicaid Services CMS to access these files entails significant paper ...

DESCRIPTION provided by applicant Autoimmune diseases like rheumatoid arthritis RA develop when the immune response targets self antigens leading to inflammation and tissue destruction There is now considerable evidence that recognition of self nucleic acids through toll like receptors TLRs can contribute significantly to sterile inflammation and autoimmunity with the clearest example b ...

DESCRIPTION provided by applicant Aging populations have become a key target for therapeutics developers particularly for indications impacting cognitive function Conditions such as Alzheimerandapos s disease and vascular dementia affect the quality of life of aging Americans largely due to their impact on cognitive function with insufficient therapeutic options Recent reports indicate tha ...

DESCRIPTIONprovided by applicantAllergic asthma is a multi faceted inflammatory disease in the lungIgE and Thmediated inflammation play a critical role in extrinsic allergic asthmaOur labs have identified naturally processed IgE cytotoxic peptidesnECPon IgE producing cellswhich serve as CTL vaccineThe feasibility of using nECP with helper peptide PADRE as a universal IgE vaccineor vaccineto treat ...

DESCRIPTION provided by applicant Respiratory syncytial virus RSV is a leading cause of lower respiratory tract disease leading annually to deaths and million hospitalizations of young children worldwide Immune prophylaxis with a monoclonal antibody mAb Synagis tm Medimmune Inc was shown to be effective years ago to reduce complications of infection in premature birth ...

Abstract Chlamydia trachomatis Ct is the most common cause of bacterial sexually transmitted diseases STD with million annual cases worldwide and million U S cases in Most female and male infections are asymptomatic facilitating unchecked transmission that can result in pelvic inflammatory disease infertility chronic pelvic pain and life threatening ectopic pregnancy Ct ...

DESCRIPTION provided by applicant Osteoporosis affects million Americans and another million are osteopenic and at risk for developing osteoporosis Since the s bisphosphonate drug therapy has produced clinical benefits such as improved bone density and reduced fracture risk by slowing osteoclastic bone resorption Many of the existing anti resorptive drugs are plagued with untowar ...

DESCRIPTION provided by applicant The Specific Aim of this SBIR direct to Phase II project is to develop natural repertoire recombinant intravenous immunoglobulin rIVIg andquot hyperimmunesandquot against common pathogens for patients with primary immune deficiency PID PID is a diverse family of congenital disorders including common variable immune deficiency CVID and X linked agammaglobulinemia X ...