Award Data

Abstract Bioluminescence imagingBLIsystems are installed in thousands of facilities and labsand with their straightforward and low cost workflow for longitudinal studiesare the most commonly used preclinical modality for assessing tumor models in rodentsThere currently is no high throughput and low cost system enabling BLI images to be combined with anatomical images of soft tissue to confirm tumo ...

Chikungunya virusCHIKVis an alphavirus that has gained significant attention due to its ability to cause large epidemics among susceptible populations and to be spread beyond endemic countries by international travelersAmong a population of approximatelyon the French island of La Reunionpeople were infected and overCHIKV related fatalities occurred during theoutbreakLikewisean estimatedmillion peo ...

n psychiatry clinical judgment has been the predominant method of diagnosis The `gold standard for clinical research is the Structured Clinical Interview for DSM SCID The SCID promotes reliability but its validity is questionable There is growing recognition that biomarkers can be used to identify more homogeneous patient populations but there is substantial phenotypic discordance f ...

PROJECT SUMMARYABSTRACT Chronic respiratory diseasessuch as COPDasthmaand cystic fibrosisCFare therd leading cause of death in the USwith costs exceeding $B yearA major obstacle to evaluate therapies for these diseases is that currently available tools to assess lung function are either insensitive to early disease or unsuitable for longitudinal useThough ubiquitouspulmonary function testing via s ...

PROJECT SUMMARY Heart attackor acute myocardial infarctionAMIis a leading cause of death in the United Stateswith overvictims every yearThe most prevalent cause of AMI is progressive thrombotic coronary artery occlusionalso known as ST segment elevation myocardial infarctionSTEMIEarly therapy to promote heart reperfusion can dramatically improve outcomesWhile percutaneous coronary interventionPCIi ...

In this Phase II SBIR applicationExperiad Solutions proposes to complete the development of Motivitya new type of software that has the potential to modernize the practice of behavioral therapy for autismApplied Behavior AnalysisABAis an evidence based autism treatment that is practiced by overBoard Certified Behavior AnalystsBCBAsin the USBCBAs analyze a child s unique needsthen construct an indi ...

Abstract There has been substantial progress in developing evidence based prevention programsEBPPsfor preventing risky behaviors and promoting positive mental health outcomes for youthUnfortunatelyEBPP adoptionquality implementationlong term sustainabilityand scalability in real world service settings continues to lag far behindjeopardizing the ability to achieve the intended broad scale public im ...

Abstract OsteoarthritisOAremains a significant source of significant pain and disabilityaffecting overmillion adults with an economic burden of over $billion per year to the USJoint replacement is a well established procedurebut its finite life span makes this treatment unacceptable for younger or more active individualswho often require additional revision surgeries as they ageBoth complicated re ...

With this PhasesubmissionIsoPlexis proposes to deliver a single cell proteomic solution for ultra sensitive detection of unique correlative biomarkers in pre clinical mouse modelsin an automated system that can be used to accelerate the discovery of potential immune therapeuticsThe recent revolution in new basic science discovery is failing to translate into improved patient treatmentThe reduction ...

Abstract It is estimated that only aboutof young patients suffering from!activity limiting hip osteoarthritisOAchoose to undergo traditional hip replacement surgeryThis low percentage is attributed to the shortened projected lifetime of hip implants for active patients and the subsequent need for revision surgeries that are plagued with higher complication rates and overall decreased effectiveness ...