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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development of a mobile and automated platform for multiplexed multi-modality imaging

    SBC: Sonovol, Inc.            Topic: 102

    Abstract Bioluminescence imagingBLIsystems are installed in thousands of facilities and labsand with their straightforward and low cost workflow for longitudinal studiesare the most commonly used preclinical modality for assessing tumor models in rodentsThere currently is no high throughput and low cost system enabling BLI images to be combined with anatomical images of soft tissue to confirm tumo ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a versatile robotic radiation therapy system

    SBC: Radiabeam Technologies, LLC            Topic: 102

    SignificanceRobotic radiotherapy using extensively non coplanar beams has been shown effective to significantly improve radiation therapy dosimetryleading to improved treatment outcomesHoweverthe current implementation of this technique by CyberKnife is inefficient and not dosimetrically optimalThis has severely limited both the number of patients eligible for robotic radiotherapy and the achievab ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Broadly neutralizing(BN) pan-IgE supersite vaccine for allergic asthma

    SBC: IGE THERAPEUTICS, INC.            Topic: NIAID

    ABSTRACT SUMMARY Immunoglobulin EIgEin the lung plays a key role in allergic asthmatic inflammationAsthmatic patients also exhibit elevated serum IgE levelswhich may re equilibrate with the lung IgE pool or enhance IgE mediated allergic asthmaA seminal finding of IgE downregulation by active IgE immunization was first reported in our labThis led to the product concept of the mAb omalizumaband a su ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of an H2O2-inactivated chikungunya virus vaccine

    SBC: NAJIT TECHNOLOGIES, INC.            Topic: R

    Chikungunya virusCHIKVis an alphavirus that has gained significant attention due to its ability to cause large epidemics among susceptible populations and to be spread beyond endemic countries by international travelersAmong a population of approximatelyon the French island of La Reunionpeople were infected and overCHIKV related fatalities occurred during theoutbreakLikewisean estimatedmillion peo ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Web Software to develop an RDoC Compatible Adaptive Diagnostic Nosology the SID

    SBC: Health Outcomes Inc            Topic: 102

    n psychiatry clinical judgment has been the predominant method of diagnosis The `gold standard for clinical research is the Structured Clinical Interview for DSM SCID The SCID promotes reliability but its validity is questionable There is growing recognition that biomarkers can be used to identify more homogeneous patient populations but there is substantial phenotypic discordance f ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Improved Diagnosis of Kaposi's Sarcoma-Associated Herpesvirus Infection

    SBC: EPIPHANY BIOSCIENCES, INC.            Topic: R

    Project Summary Abstract Kaposiandapos s sarcoma herpes virusKSHVis an oncovirus that causes several cancers including Kaposiandapos s sarcomaKSIt is estimated thattoof U Sblood donors have been infected with KSHVyet in some high risk populations such as homosexual menprevalence is as high asIn spite of HAARTKS remains the second most common AIDSassociated malignancyA third of AIDS KS cases now ar ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Portable Hearing Laboratory

    SBC: BATANDCAT            Topic: NIDCD

    The National Institute on Deafness and Other Communication DisordersNIDCDhas recently funded a number of projectsreferred further to asconcurrent projectsto develop portable signal processing tools that provide substantial computing power for real time processing of the acoustic environmentThe overarching goal is to provide a large group of researchersCommunitywith the means to ef ciently develop ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung Disease

    SBC: POLAREAN, INC.            Topic: NHLBI

    PROJECT SUMMARYABSTRACT Chronic respiratory diseasessuch as COPDasthmaand cystic fibrosisCFare therd leading cause of death in the USwith costs exceeding $B yearA major obstacle to evaluate therapies for these diseases is that currently available tools to assess lung function are either insensitive to early disease or unsuitable for longitudinal useThough ubiquitouspulmonary function testing via s ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Therapeutic Protein C Activator for Myocardial Ischemia

    SBC: Aronora, Inc            Topic: NHLBI

    PROJECT SUMMARY Heart attackor acute myocardial infarctionAMIis a leading cause of death in the United Stateswith overvictims every yearThe most prevalent cause of AMI is progressive thrombotic coronary artery occlusionalso known as ST segment elevation myocardial infarctionSTEMIEarly therapy to promote heart reperfusion can dramatically improve outcomesWhile percutaneous coronary interventionPCIi ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. CARDIOVASCULAR PATCH PROTECTION SYSTEM USING A DURABLE, SELF-SEALING MATERIAL

    SBC: SOLINAS MEDICAL INC.            Topic: NHLBI

    Project Summary This Small Business Innovation Research Phase II project supports the development of an instantly sealing vessel protection platform with enhanced durability against needle sticks While Medicare spends over $ billion annually on the treatment for end stage renal disease greater than of its budget $ billion is spent treating preventable access related complications Many ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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